Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.

Abstract

BACKGROUND: Resveratrol has shown health benefits like anti-obesity, antioxidant, and anti-inflammatory effects. OBJECTIVES: To resolve conflicting findings and clarify its impact, our study summarizes resveratrol supplementation’s effects and evaluates its effectiveness across populations. METHODS: We conducted the search through PubMed, Embase, and Web of Science databases from inception to April 30th, 2025, to identify meta-analyses of randomized controlled trials examining the effects of resveratrol supplementation on human health. The quality of included studies was evaluated using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) tool, and the credibility of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. This study was registered in PROSPERO (CRD 42024554480). RESULTS: Forty-five systematic reviews with 129 associations between resveratrol supplementation and human health were included, which consists of 68 outcomes. Using the AMSTAR measurement tool, all articles were categorized as moderate-to-high quality. Among 35 significant associations, four were supported by high-certainty evidence according to GRADE, including positive effects of resveratrol supplementation on reducing waist circumference (mean difference [MD] = -0.80 cm, 95% CI = -1.40, -0.20), total cholesterol among overweight adults (MD = -0.19 mmol/L, 95% CI = -0.32, -0.06), diastolic blood pressure (MD = -3.55 mmHg, 95% CI = -5.18, -1.93) and systolic blood pressure (MD = -7.97 mmHg, 95% CI = -10.63, -5.31) among patients with type 2 diabetes. Moreover, moderate-certainty evidence indicated that resveratrol supplementation may promote glucose metabolism, improve renal function, protect endothelial health, enhance working memory, improve hepatic steatosis, lower hormones, and reduce inflammation. CONCLUSIONS: High certainty of evidence suggested that resveratrol supplementation could decline waist circumference, lower blood pressure among patients with type 2 diabetes, and reduce total cholesterol among overweight adults.