A timeline of tau-mediated synaptotoxicity.

IF 15.7 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2026-05-01 Epub Date: 2026-04-11 DOI:10.1016/j.tins.2026.03.011

Calum K Bonthron, Claire S Durrant

引用次数: 0

Abstract

Oligomeric tau has been increasingly implicated in synaptic impairments observed in Alzheimer's disease. In a recent study, Pareja-Navarro and colleagues provide insights into the precise timeline of synaptic deficits induced by oligomeric forms of tau. Such knowledge could aid in the design of therapeutic interventions to prevent synaptic loss.

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tau介导的突触毒性的时间轴。

寡聚tau蛋白越来越多地与阿尔茨海默病中观察到的突触损伤有关。在最近的一项研究中，Pareja-Navarro及其同事提供了由tau寡聚形式引起的突触缺陷的精确时间线的见解。这些知识可以帮助设计治疗干预措施，以防止突触丧失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.