EEG Signatures of COVID-19 Survival compared to close contacts and the Cuban EEG normative database

IF 2.3 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-03-01 DOI:10.1016/j.cnp.2026.02.007

Ana Calzada-Reyes , Lidice Galán-García , Trinidad Virués-Alba , Lidia Charroó-Ruiz , Laura Perez-Mayo , Maria Luisa Bringas-Vega , Jorge Bosch-Bayard , Yanely Acosta-Ymas , Eduardo Aubert-Vázquez , Mayrim Vega-Hernández , Joel Gutiérrez-Gil , Antonio Caballero-Moreno , Annette Valdés-Virués , Mitchell Valdés-Sosa , Peng Ren , Dezhong Yao , Luo Cheng , Roberto Rodriguez-Labrada , Pedro Valdés-Sosa

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引用次数: 0

Abstract

Objective

This study compared EEG findings in COVID-19 survivors, close contacts, and a normative database using visual EEG inspection, quantitative EEG (QEEG), and source density analysis.

Methods

Resting-state EEG, QEEG, and VARETA inverse solution were analyzed in 173 participants (87 COVID-19 cases, 86 close contacts) alongside the Cuban EEG normative database. Clinical evaluations included neurological exams and neuropsychiatric assessments.

Results

COVID-19 survivors showed significant EEG abnormalities, including background abnormalities, focal abnormalities and diffuse slow activity. QEEG revealed excess theta, alpha, and beta activity in COVID-19 and symptomatic groups, while close contacts had elevated alpha and beta. EEG source analysis identified functional impairments in key brain regions: COVID-19 patients had abnormalities in the supramarginal and angular gyri, while close contacts showed abnormalities in the supramarginal, postcentral, and superior temporal gyri. Symptomatic individuals exhibited superior temporal gyrus abnormalities, whereas asymptomatic cases had impairments in the supramarginal, angular, and postcentral gyri.

Conclusions

Long-term COVID-19 impacts brain function, with QEEG and VARETA revealing region-specific vulnerabilities linked to viral exposure. These tools help assess neurological dysfunction in post-COVID cases.

Significance

This approach is crucial for understanding the COVID-19 long-term effects on brain function and guiding potential therapeutic interventions.

查看原文本刊更多论文

与密切接触者和古巴脑电图规范数据库比较的COVID-19存活者脑电图特征

目的采用目视脑电图检查、定量脑电图（QEEG）和传染源密度分析方法，比较新冠肺炎幸存者、密切接触者和规范数据库的脑电图结果。方法对173例（新冠肺炎病例87例，密切接触者86例）的静息状态EEG、QEEG和VARETA逆解进行分析，并结合古巴EEG规范数据库进行分析。临床评估包括神经学检查和神经精神学评估。结果scovid -19存活者脑电图异常明显，包括背景异常、局灶性异常和弥漫性慢活动。QEEG显示，COVID-19和症状组的α、α和β活性过高，而密切接触者的α和β活性升高。脑电源分析发现关键脑区功能损伤：新冠肺炎患者在边缘上回和角回出现异常，而密切接触者在边缘上回、中央后回和颞上回出现异常。有症状的个体表现为颞上回异常，而无症状的病例则表现为边缘上、角回和中央后回的损伤。长期的COVID-19会影响大脑功能，QEEG和VARETA揭示了与病毒暴露相关的区域特异性脆弱性。这些工具有助于评估covid - 19后病例的神经功能障碍。该方法对于了解COVID-19对脑功能的长期影响并指导潜在的治疗干预措施至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.