Cold Atmospheric Plasma Applications in Viral Inactivation: Systematic Review and Metanalysis

IF 3.5 3区物理与天体物理 Q3 ENGINEERING, CHEMICAL

Plasma Chemistry and Plasma Processing Pub Date : 2026-02-09 DOI:10.1007/s11090-025-10611-x

Pasquale Isabelli, Daniela Boehm, Cristina Canal, Matteo Gherardi, Romolo Laurita

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引用次数: 0

Abstract

This work is a systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A predefined protocol was followed to ensure a transparent, reproducible, and methodologically rigorous selection and analysis of the available literature on the use of cold plasma for viral inactivation. Cold atmospheric plasma (CAP) technology has emerged as a promising tool for combating viruses. This study presents a systematic review of current knowledge regarding CAP applications in virology. A comprehensive search was conducted across Scopus and Web of Science databases, including studies published between 2000 and 2024 that explored the use of CAP in virology. Following the guidelines outlined by PRISMA, 160 articles were identified and categorized into six categories. The analysis highlighted a notable increase in publications within this field since 2020, coinciding with the emergence of COVID-19. Geographically, the United States emerged as the leading contributor to research in this area, accounting for 21.9% of the publications. Among the identified articles, 20.6% were classified as reviews, while the remaining 79.4% comprised research studies. Data extraction focused on publication year, last author’s country affiliation, CAP source type, targeted applications, and investigated virus species. Fundamental research constituted the largest category of articles (34.4%), followed by studies exploring surface decontamination via CAP technology (18.8%). Dielectric barrier discharges (DBDs) were identified as the most prevalent CAP source employed in the studies, representing 26% of all cases. Analysis of the included experimental articles showed investigations encompassing 42 distinct viral species. RNA viruses emerged as the most extensively studied group, accounting for 76.2% of the research focus. The findings of this systematic review demonstrate the effectiveness of CAP in inactivating a broad spectrum of viruses. This includes both enveloped and non-enveloped viruses and DNA and RNA viruses affecting humans, animals, and plants. CAP-mediated viral inactivation is likely mediated by a multiplicity mechanism involving direct damage to viral particles, viral replication disruption, and host immune response modulation.

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低温常压等离子体在病毒灭活中的应用：系统综述和荟萃分析

这项工作是根据PRISMA（系统评价和荟萃分析的首选报告项目）指南进行的系统评价。遵循预先确定的方案，以确保透明、可重复性和方法上严格的选择和分析使用冷血浆进行病毒灭活的现有文献。冷大气等离子体（CAP）技术已成为一种很有前途的对抗病毒的工具。本研究对目前CAP在病毒学中的应用进行了系统的综述。在Scopus和Web of Science数据库中进行了全面的搜索，包括2000年至2024年间发表的探索CAP在病毒学中的应用的研究。根据PRISMA概述的指导方针，确定了160篇文章并将其分为六类。该分析强调，自2020年以来，该领域的出版物显著增加，恰逢COVID-19的出现。从地理上看，美国成为该领域研究的主要贡献者，占出版物的21.9%。在确定的文章中，20.6%归类为综述，其余79.4%为研究。数据提取侧重于出版年份、最后一位作者所属国家、CAP源类型、目标应用和调查的病毒种类。基础研究占文章的最大类别（34.4%），其次是通过CAP技术探索表面净化的研究（18.8%）。介质阻挡放电（DBDs）被确定为研究中最常见的CAP源，占所有病例的26%。对纳入的实验文章的分析显示，调查涉及42种不同的病毒种类。RNA病毒成为研究最广泛的一类病毒，占研究重点的76.2%。本系统综述的发现证明了CAP在灭活多种病毒方面的有效性。这包括包膜病毒和非包膜病毒，以及影响人类、动物和植物的DNA和RNA病毒。cap介导的病毒失活可能是由多种机制介导的，包括对病毒颗粒的直接损伤、病毒复制中断和宿主免疫反应调节。

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来源期刊

Plasma Chemistry and Plasma Processing 工程技术-工程：化工

CiteScore

5.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Publishing original papers on fundamental and applied research in plasma chemistry and plasma processing, the scope of this journal includes processing plasmas ranging from non-thermal plasmas to thermal plasmas, and fundamental plasma studies as well as studies of specific plasma applications. Such applications include but are not limited to plasma catalysis, environmental processing including treatment of liquids and gases, biological applications of plasmas including plasma medicine and agriculture, surface modification and deposition, powder and nanostructure synthesis, energy applications including plasma combustion and reforming, resource recovery, coupling of plasmas and electrochemistry, and plasma etching. Studies of chemical kinetics in plasmas, and the interactions of plasmas with surfaces are also solicited. It is essential that submissions include substantial consideration of the role of the plasma, for example, the relevant plasma chemistry, plasma physics or plasma–surface interactions; manuscripts that consider solely the properties of materials or substances processed using a plasma are not within the journal’s scope.