Saima Aamir, Nosheen Mahmood, Nada A Alhumrani, Wateen A Alshawi, Layan A Alyaeesh, Aseel A Alqarni, Lubna A Alagla, Sadal G Refae
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引用次数: 0
Abstract
Background: Breast cancer is a leading cause of cancer-related deaths globally, with a rising incidence in Saudi Arabia. However, limited studies from Saudi Arabia have reported the molecular subtypes and prognostic biomarkers of breast cancer.
Objectives: This study aimed at comparing the clinicopathological and immunohistochemical characteristics of breast cancer among two age groups from Saudi Arabia.
Methods: A retrospective study was conducted on Saudi female patients diagnosed with breast cancer between 2017 and 2022 at a tertiary care hospital in Riyadh. Patients were stratified into two age groups: aged ≤40 years and >40 years. Tumor size, grade, stage, and molecular subtypes were compared among these age groups.
Results: The study comprised 300 females with breast cancer (mean age: 53.2 ± 12.6 years). Majority of patients (54.3%) were postmenopausal. The most common tumor type overall was invasive breast carcinoma of no special type (84%). In patients aged ≤40 years, most patients had T4 tumor size (39%) and were at an advanced stage (69.2%). Compared with those aged >40 years, patients aged ≤40 years had significantly higher Ki-67 index (P < 0.001), lymph node spread (P = 0.009) and poor short-term survival (P < 0.024). Luminal A tumors were more common in the older age group, while significantly higher proportion of young patients had triple negative breast cancer (TNBC) (P = 0.035). Cox regression analysis demonstrated advanced stage (hazard ratio [HR]: 12.4; P = 0.002) and TNBC (HR: 11.9; P = 0.002) as factors that raised the risk of mortality compared to early stage and luminal A type, respectively.
Conclusion: Breast cancer patients aged ≤40 years exhibited more aggressive clinicopathological features, including higher grade, advanced stage, triple negative receptor status, and poorer short-term survival compared with patients aged >40 years.
期刊介绍：
Saudi Journal of Medicine & Medical Sciences (SJMMS) is the official scientific journal of Imam Abdulrahman Bin Faisal University. It is an international peer-reviewed, general medical journal. The scope of the Journal is to publish research that will be of interest to health specialties both in academic and clinical practice. The Journal aims at disseminating high-powered research results with the objective of turning research into knowledge. It seeks to promote scholarly publishing in medicine and medical sciences. The Journal is published in print and online. The target readers of the Journal include all medical and health professionals in the health cluster such as in medicine, dentistry, nursing, applied medical sciences, clinical pharmacology, public health, etc.
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