The Association of Dietary Patterns with Age-Related Macular Degeneration in a Multiethnic Older Singaporean Population.

IF 2.3 4区医学 Q2 OPHTHALMOLOGY

Ophthalmologica Pub Date : 2026-01-01 Epub Date: 2026-01-17 DOI:10.1159/000550522

Yijia Zhang, Preeti Gupta, Eva Fenwick, Ryan Man, Chiew Meng Johnny Wong, Anna Cheng Sim Tan, Chui Ming Gemmy Cheung, Marjorelee T Colega, Mary Foong-Fong Chong, Jun S Lai, Ecosse Luc Lamoureux

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引用次数: 0

Abstract

Introduction: The associations of dietary patterns and age-related macular degeneration (AMD) have been reported using mostly Western and Japanese populations and evidence in multiethnic Asian populations, with potentially different dietary patterns, is lacking. In this study, we aimed to identify dietary patterns in a multiethnic older Singaporean population and examine their associations with AMD.

Methods: This was a cross-sectional analysis of the Population Health and Eye Disease Profile in Elderly Singaporeans (PIONEER) study. Dietary intake was assessed using a 110-item interviewer-administered food frequency questionnaire validated in a Singaporean population. Presence and stage of AMD were categorized using fundus photographs and an established AMD classification. Dietary patterns were generated by applying exploratory factor analysis, and their associations with presence of AMD and stage of AMD were evaluated using adjusted logistic regression models and adjusted multinomial logistic regression models, respectively.

Results: Of 1,480 Chinese, Malay, and Indian individuals aged ≥60 years (mean 71.3 ± 7.7), age-standardized prevalence of any, early, and late AMD were 7.1%, 4.8%, and 2.2%. Three dietary patterns were generated: "snacks, fried foods, and refined carbohydrates"; "poultry, meat, and Fish"; and "wholemeal bread, legumes, and nuts." After adjusting for covariates, higher "snacks, fried foods, and refined carbohydrates" pattern scores were associated with higher odds of any AMD (OR = 1.41, 95% CI: 1.02-1.96) and early AMD (OR = 1.63, 95% CI: 1.12-2.37). "Snacks, fried foods, and refined carbohydrates" pattern scores in the highest quartile were associated with higher odds of any AMD (OR = 2.18, 95% CI: 1.01-4.72), compared to the lowest quartile.

Conclusion: Only the "snacks, fried foods, and refined carbohydrates" pattern was associated with AMD in this multiethnic older Singaporean population. These findings may inform the development of dietary guidelines in Singapore for more targeted AMD management, although prospective, longitudinal data are needed.

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新加坡多民族老年人群饮食模式与年龄相关性黄斑变性的关系

饮食模式与年龄相关性黄斑变性（AMD）之间的关联已被报道，主要是在西方和日本人群中，而在饮食模式可能不同的多民族亚洲人群中缺乏证据。在这项研究中，我们旨在确定新加坡多民族老年人的饮食模式，并研究其与AMD的关系。方法：这是对新加坡老年人人口健康和眼病概况（PIONEER）研究的横断面分析。膳食摄入量评估使用110项访谈者管理的食物频率问卷在新加坡人群中验证。根据眼底照片和已建立的AMD分类对AMD的存在和分期进行分类。采用探索性因子分析生成饮食模式，并分别采用调整后的logistic回归模型和调整后的多项logistic回归模型评估饮食模式与AMD存在程度和AMD分期的关系。结果：1480名年龄≥60岁的华人、马来人和印度人（平均71.3±7.7）中，任何、早期和晚期AMD的年龄标准化患病率分别为7.1%、4.8%和2.2%。产生了三种饮食模式：“零食、油炸食品和精制碳水化合物”；“家禽、肉类和鱼类”；以及“全麦面包、豆类和坚果”。在调整了相关变量后，较高的“零食、油炸食品和精制碳水化合物”模式得分与任何AMD （OR=1.41, 95%CI: 1.02-1.96）和早期AMD （OR=1.63, 95%CI: 1.12-2.37）的几率较高相关。与最低四分位数相比，“零食、油炸食品和精制碳水化合物”模式得分最高的四分位数与任何AMD的几率更高相关（OR=2.18, 95%CI: 1.01-4.72）。结论：在新加坡多民族老年人群中，只有“零食、油炸食品和精制碳水化合物”模式与AMD有关。尽管需要前瞻性的纵向数据，但这些发现可能会为新加坡制定更有针对性的AMD管理饮食指南提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.