The global research hotspots and future trends of infantile epileptic spasms syndrome: A bibliometric analysis of trends and themes

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Brain & Development Pub Date : 2026-02-01 Epub Date: 2026-01-16 DOI:10.1016/j.braindev.2026.104500

Zhenzhen Wang , Danqing Hu , Xin Dong , Wei Zhou

{"title":"The global research hotspots and future trends of infantile epileptic spasms syndrome: A bibliometric analysis of trends and themes","authors":"Zhenzhen Wang , Danqing Hu , Xin Dong , Wei Zhou","doi":"10.1016/j.braindev.2026.104500","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate research trends, key contributors, and emerging topics in the field of infantile epileptic spasms syndrome (IESS).</div></div><div><h3>Methods</h3><div>Publications on IESS from 1954 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using Microsoft Excel, VOSviewer, CiteSpace, and R version 4.3.3.</div></div><div><h3>Results</h3><div>A total of 2905 publications were identified, revealing a marked increase in research output from 2000 onward. The USA led with 760 publications. The University of California System was the most productive institution, contributing 420 papers. <em>Epilepsia</em> was the most influential journal, publishing 371 papers with 12,246 citations. Leading authors included Naomichi Matsumoto and Ingrid E. Scheffer. Keywords formed five thematic clusters: (1) genetic foundations and molecular mechanisms (e.g., “mutations”), (2) therapeutic strategies for seizure control (e.g., “ketogenic diet”), (3) epidemiological patterns and seizure classification (e.g., “classification”), (4) clinical practices and treatment outcomes (e.g., “vigabatrin”), and (5) brain structure and diagnostic imaging (e.g., “MRI”). Burst keyword analysis indicated a focus on terms including “encephalopathy”, “epileptic spasms”, “intellectual disability”, “ilae commission”, “hypsarrhythmia”, “classification”, “multicenter”, and “management”.</div></div><div><h3>Conclusion</h3><div>The findings highlight current hotspots spanning genetic mechanisms, therapeutic strategies, epidemiological patterns, clinical practices, and neuroimaging. Future research should optimize treatments, improve diagnostics, and address developmental impacts.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"48 1","pages":"Article 104500"},"PeriodicalIF":1.3000,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain & Development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S038776042600001X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/16 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study aims to investigate research trends, key contributors, and emerging topics in the field of infantile epileptic spasms syndrome (IESS).

Methods

Publications on IESS from 1954 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using Microsoft Excel, VOSviewer, CiteSpace, and R version 4.3.3.

Results

A total of 2905 publications were identified, revealing a marked increase in research output from 2000 onward. The USA led with 760 publications. The University of California System was the most productive institution, contributing 420 papers. Epilepsia was the most influential journal, publishing 371 papers with 12,246 citations. Leading authors included Naomichi Matsumoto and Ingrid E. Scheffer. Keywords formed five thematic clusters: (1) genetic foundations and molecular mechanisms (e.g., “mutations”), (2) therapeutic strategies for seizure control (e.g., “ketogenic diet”), (3) epidemiological patterns and seizure classification (e.g., “classification”), (4) clinical practices and treatment outcomes (e.g., “vigabatrin”), and (5) brain structure and diagnostic imaging (e.g., “MRI”). Burst keyword analysis indicated a focus on terms including “encephalopathy”, “epileptic spasms”, “intellectual disability”, “ilae commission”, “hypsarrhythmia”, “classification”, “multicenter”, and “management”.

Conclusion

The findings highlight current hotspots spanning genetic mechanisms, therapeutic strategies, epidemiological patterns, clinical practices, and neuroimaging. Future research should optimize treatments, improve diagnostics, and address developmental impacts.

查看原文本刊更多论文

婴儿癫痫痉挛综合征全球研究热点及未来趋势：趋势与主题的文献计量学分析

目的探讨婴儿癫痫性痉挛综合征（IESS）的研究趋势、主要贡献者和新兴课题。方法从Web of Science Core Collection （WoSCC）数据库中检索1954 ~ 2024年有关国际空间站的出版物。使用Microsoft Excel、VOSviewer、CiteSpace和R version 4.3.3进行文献计量学分析。结果共发现2905篇论文，显示了自2000年以来研究产出的显著增长。美国以760篇论文排名第一。加州大学系统是最多产的机构，发表了420篇论文。《癫痫病》是最具影响力的期刊，发表论文371篇，被引用12246次。主要作者包括Naomichi Matsumoto和Ingrid E. Scheffer。关键词形成了五个主题集群：(1)遗传基础和分子机制（如“突变”），(2)控制癫痫发作的治疗策略（如“生酮饮食”），(3)流行病学模式和癫痫发作分类（如“分类”），(4)临床实践和治疗结果（如“vigabatrin”），以及(5)脑结构和诊断成像（如“MRI”）。突发关键词分析显示，人们关注的关键词包括“脑病”、“癫痫性痉挛”、“智力残疾”、“ilae委员会”、“心律失常”、“分类”、“多中心”和“管理”。结论研究结果突出了当前的热点，包括遗传机制、治疗策略、流行病学模式、临床实践和神经影像学。未来的研究应优化治疗，提高诊断，并解决发展影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.