Choline transporters fueling the great myelin expansion.

IF 15.7 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2026-01-01 Epub Date: 2025-12-31 DOI:10.1016/j.tins.2025.12.001

Aksheev Bhambri, Lu O Sun

引用次数: 0

Abstract

Myelin formation involves massive lipid production, which requires extensive choline uptake and metabolism. Highlighting two recent studies conducted by Liu et al. and Chen et al., we discuss the identification of Slc44a1 as the primary oligodendrocyte choline transporter. These findings establish choline import as an evolutionarily conserved checkpoint for oligodendrocyte differentiation and central nervous system myelination.

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胆碱转运体促进髓磷脂扩张。

髓磷脂的形成涉及大量的脂质产生，这需要广泛的胆碱摄取和代谢。重点介绍Liu等人和Chen等人最近进行的两项研究，我们讨论了Slc44a1作为主要少突胶质细胞胆碱转运蛋白的鉴定。这些发现确立了胆碱输入作为少突胶质细胞分化和中枢神经系统髓鞘形成的进化保守检查点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.