A review of the neuropharmacological profile of schedule-induced polydipsia

IF 1.9 3区心理学 Q4 BEHAVIORAL SCIENCES

Journal of the experimental analysis of behavior Pub Date : 2025-12-17 DOI:10.1002/jeab.70069

Robert Lalonde, Catherine Strazielle

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引用次数: 0

Abstract

Schedule-induced polydipsia (SIP) arises when subjects consume excessive amounts of water during interval responding on operant tasks, a paradigm introduced and mostly developed in rats. Neuropharmacological studies conducted on SIP have mainly shown a prominent role of dopamine and 5HT in this adjunctive behavior. In particular, D₁/D₂ receptor antagonists decrease SIP, whereas low doses of dopamine reuptake blockers increase SIP. There is more specific evidence of a decline in SIP after lesions of the mesolimbic dopamine pathway. A decline in SIP is likewise observed after the injection of 5HT reuptake blockers and modulated by 5HT_2A/5HT_2C receptor agonists and antagonists. Despite more limited studies with other neurotransmitter systems, SIP has so far been shown to decline after the injection of muscarinic or NMDA receptor antagonists as well as benzodiazepine receptor agonists. Under some conditions, the role of neuroendocrine factors is shown by alterations in blood corticosterone levels during the course of SIP, indicative of its stress-reducing properties.

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计划性烦渴的神经药理学研究综述。

计划性多饮（SIP）发生在受试者在操作任务间歇反应期间摄入过量的水时，这是一种主要在大鼠中引入和发展的范式。对SIP的神经药理学研究主要显示了多巴胺和5HT在这种辅助行为中的突出作用。特别是，D1/D2受体拮抗剂降低SIP，而低剂量的多巴胺再摄取阻滞剂增加SIP。有更具体的证据表明，中边缘多巴胺通路病变后，SIP下降。同样，在注射5HT再摄取阻滞剂后，观察到SIP下降，并由5HT2A/5HT2C受体激动剂和拮抗剂调节。尽管对其他神经递质系统的研究比较有限，但到目前为止，SIP已被证明在注射毒毒碱或NMDA受体拮抗剂以及苯二氮卓受体激动剂后下降。在某些情况下，神经内分泌因子的作用通过在SIP过程中血液皮质酮水平的改变来显示，这表明其具有减轻压力的特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the experimental analysis of behavior 医学-行为科学

CiteScore

3.90

自引率

14.80%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of the Experimental Analysis of Behavior is primarily for the original publication of experiments relevant to the behavior of individual organisms.