Systemic inflammatory indices as biomarkers in adolescents with methamphetamine use disorder: a case-control study.

IF 1.7 4区医学 Q3 SUBSTANCE ABUSE

Journal of Addictive Diseases Pub Date : 2026-10-01 Epub Date: 2025-12-07 DOI:10.1080/10550887.2025.2595156

Mustafa Tolga Tunagur, Elif Merve Kurt Tunagur

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引用次数: 0

Abstract

Background: Despite the rising prevalence of methamphetamine use disorder (MUD) among adolescents and its severe consequences, data on hematological inflammatory indices in this population remain limited.

Objectives: This study aimed to evaluate systemic inflammatory markers in adolescents with MUD and their associations with addiction severity.

Methods: The retrospective case-control study included 44 adolescents with MUD and 44 age- and gender-matched healthy controls. Hematological indices were calculated from complete blood count data, including neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), Basophil-to-lymphocyte ratio (BLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). Group comparisons, receiver operating characteristic (ROC) analyses, and partial correlations were performed.

Results: The MUD group included 30 females (68.2%) and 14 males (31.8%); the control group included 25 females (56.8%) and 19 males (43.2%). Adolescents with MUD showed significantly higher neutrophil and platelet counts, NLR, dNLR, PLR, MLR, SII, SIRI, and AISI, alongside reduced lymphocyte counts, compared with controls (all p < .05). ROC analyses revealed good discriminative ability for SII (AUC = 0.79), AISI (AUC = 0.73), and SIRI (AUC = 0.69). Several indices, including NLR, PLR, and SII, correlated negatively with treatment motivation, while PLR and MLR correlated positively with diagnostic severity.

Conclusions: Adolescents with MUD demonstrate marked systemic inflammatory alterations detectable through routine hematological indices. These markers may serve as low-cost, clinically accessible biomarkers for identifying high-risk individuals and monitoring disease severity, with implications for early intervention and personalized treatment.

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系统性炎症指标作为甲基安非他命使用障碍青少年的生物标志物：一项病例对照研究。

背景：尽管甲基苯丙胺使用障碍（MUD）在青少年中的患病率上升及其严重后果，但这一人群的血清学炎症指数数据仍然有限。目的：本研究旨在评估青少年MUD的全身炎症标志物及其与成瘾严重程度的关系。方法：回顾性病例对照研究包括44例青少年MUD和44例年龄和性别匹配的健康对照。根据全血细胞计数数据计算血液学指标，包括中性粒细胞与淋巴细胞比值（NLR）、衍生性NLR （dNLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、嗜碱性粒细胞与淋巴细胞比值（BLR）、全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）和全身炎症聚集指数（AISI）。进行分组比较、受试者工作特征（ROC）分析和偏相关分析。结果：MUD组女性30例（68.2%），男性14例（31.8%）；对照组女性25例（56.8%），男性19例（43.2%）。与对照组相比，青少年MUD患者的中性粒细胞和血小板计数、NLR、dNLR、PLR、MLR、SII、SIRI和AISI显著升高，同时淋巴细胞计数降低（均p < 0.05）。ROC分析显示SII （AUC = 0.79）、AISI （AUC = 0.73）和SIRI （AUC = 0.69）具有良好的判别能力。NLR、PLR和SII等指标与治疗动机呈负相关，而PLR和MLR与诊断严重程度呈正相关。结论：青少年MUD表现出明显的全身炎症改变，可通过常规血液学指标检测到。这些标志物可以作为低成本、临床可获得的生物标志物，用于识别高风险个体和监测疾病严重程度，对早期干预和个性化治疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addictive Diseases SUBSTANCE ABUSE-

CiteScore

4.30

自引率

4.30%

发文量

期刊介绍： The Journal of Addictive Diseases is an essential, comprehensive resource covering the full range of addictions for today"s addiction professional. This in-depth, practical journal helps you stay on top of the vital issues and the clinical skills necessary to ensure effective practice. The latest research, treatments, and public policy issues in addiction medicine are presented in a fully integrated, multi-specialty perspective. Top researchers and respected leaders in addiction issues share their knowledge and insights to keep you up-to-date on the most important research and practical applications.