The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades

IF 15.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2026-01-01 Epub Date: 2025-11-24 DOI:10.1016/j.arr.2025.102959

Yucheng Luo , Yuang Song , Minxi Zeng , Bin Li , Ye Li , Ziqing Dong

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引用次数: 0

Abstract

Aging is one of the factors for the decline in adipose tissue browning and, consequently, age-related metabolic disorders. Metabolic disorders will in turn accelerate aging and lead to a vicious circle. Therefore, the research on the reduced browning of adipose tissue that occurs with aging, that is, adipose tissue browning aging, is necessary and of great significance for the development of metabolically healthy aging. In this study, we performed a bibliometric analysis of 2527 published articles on aging of adipose tissue browning and created a panorama from different levels so that readers could quickly understand the current state of the research field. The burst analysis and timeline analysis were used to identify the research frontiers in the field, and the newly published documents were discussed and summarized. In addition, we performed bioinformatic analysis on the GEO-derived dataset to identify the altered genes and enriched pathways associated with browning during aging. Combined with bibliometric analysis, the most concerned pathway was identified as adipogenesis, and the most concerned genes were PPARG, ADIPOQ and TG. In summary, this study provided a comprehensive picture of the current status of adipose tissue browning and aging research and identified research frontiers. Finally, the pathways and genes of most interest were identified by combined bioinformatic analysis.

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脂肪组织褐变和衰老的过去、现在和未来：结合文献计量学和生物信息学对过去40年发表的2527篇文献的回顾

衰老是脂肪组织褐变减少的因素之一，因此，与年龄相关的代谢紊乱。代谢紊乱反过来又会加速衰老，导致恶性循环。因此，研究随着年龄增长而发生的脂肪组织褐变减少，即脂肪组织褐变衰老，对于发展代谢健康的衰老是必要的，具有重要意义。在本研究中，我们对已发表的2527篇关于脂肪组织褐变老化的文章进行了文献计量学分析，从不同的层面构建了一个全景图，以便读者能够快速了解研究领域的现状。采用突发分析和时间线分析方法识别该领域的研究前沿，并对新发表的文献进行了讨论和总结。此外，我们对geo衍生数据集进行了生物信息学分析，以确定与衰老过程中褐变相关的改变基因和富集途径。结合文献计量学分析，鉴定出最受关注的途径为脂肪生成，最受关注的基因为PPARG、ADIPOQ和TG。综上所述，本研究全面介绍了脂肪组织褐变与衰老的研究现状，明确了研究前沿。最后，通过联合生物信息学分析确定了最感兴趣的途径和基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.