Falls Prevalence and Fear of Falling in Multiple Sclerosis: A Systematic Review and Meta-Analysis.

IF 2.4 4区医学 Q3 CLINICAL NEUROLOGY

European Neurology Pub Date : 2026-01-01 Epub Date: 2025-11-06 DOI:10.1159/000549066

Vasileios Giannopapas, Vassiliki Smyrni, Dimitrios K Kitsos, Sophia Stasi, Athanasios K Chasiotis, Konstantina Stavrogianni, Alexandra Akrivaki, Evangelia-Makrina Dimitriadou, Dimitrios Tzanetakos, Daphne Bakalidou, John S Tzartos, Georgios Tsivgoulis, Sotirios Giannopoulos

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引用次数: 0

Abstract

Introduction: Approximately 50-70% of people with multiple sclerosis (MS) experience at least one fall event during their lifetime. These events can have debilitating consequences in the quality of life of the individuals' experiencing them, as they can often result in injury, extending beyond physical harm, which may negatively impact the rehabilitation process as well as their psychological well-being.

Methods: This systematic review and meta-analysis aimed to determine the proportion of one-time and repeated falls among patients with MS within a year and investigate any potential associations with demographic and disease-specific characteristics. Adhering to PRISMA guidelines, a systematic search of the MEDLINE, PubMed, Scopus, and Google Scholar databases was conducted.

Results: Results from 4,342 patients were included. The pooled proportion of one fall within a year was estimated at 28.03% (95% CI [20.21, 36.57]), and for repeated falls, 31.74% (95% CI [23.73, 40.31]). Subgroup analyses revealed significant heterogeneity, while meta-regression showed no significant associations between fall prevalence and age, EDSS, or disease duration.

Conclusion: 42.5% of patients experienced a one-time fall, while 44.7% reported repeated falls. These findings, demonstrate the significant prevalence of falls among individuals with MS, underlying the need for targeted interventions to mitigate fall risk.

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多发性硬化症患者的跌倒患病率和对跌倒的恐惧：一项系统综述和荟萃分析。

简介：大约50-70%的多发性硬化症（MS）患者一生中至少经历过一次跌倒事件。这些事件可能会对经历这些事件的个人的生活质量产生削弱性后果，因为它们通常会导致伤害，超出身体伤害，这可能会对康复过程以及他们的心理健康产生负面影响。方法：本系统综述和荟萃分析旨在确定MS患者一年内一次性和重复跌倒的比例，并调查其与人口统计学和疾病特异性特征的任何潜在关联。遵循PRISMA指南，对MEDLINE PubMed、Scopus和谷歌Scholar数据库进行系统检索。结果：纳入4342例患者的结果。一年内发生一次跌倒的总比例估计为28.03% (95% CI[20.21, 36.57])，重复跌倒的总比例为31.74% （95% CI[23.73, 40.31]）。亚组分析显示了显著的异质性，而meta回归显示跌倒患病率与年龄、EDSS或疾病持续时间之间无显著关联。结论：42.5%的患者发生过一次性跌倒，44.7%的患者发生过多次跌倒。这些发现表明，在多发性硬化症患者中，跌倒的发生率很高，因此需要有针对性的干预措施来减轻跌倒的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.