The association between cannabis use and cardiovascular outcomes among U.S. Adults, 2020–2023

IF 4.1 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2026-01-01 Epub Date: 2025-10-24 DOI:10.1016/j.addbeh.2025.108529

Ruoyan Sun , Suzanne E. Judd , Prabal K. De

{"title":"The association between cannabis use and cardiovascular outcomes among U.S. Adults, 2020–2023","authors":"Ruoyan Sun , Suzanne E. Judd , Prabal K. De","doi":"10.1016/j.addbeh.2025.108529","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>The effect of cannabis use on cardiovascular disease is mixed in the literature. This study assessed the association between cannabis use and multiple cardiovascular outcomes using recent national data from the U.S. Potential heterogenous effects by age and sex were also examined.</div></div><div><h3>Methods</h3><div>Using a national sample of 436,949 adults who were interviewed between 2020 and 2023 in BRFSS, we employed multivariable logistic regressions to determine the association between cannabis use and cardiovascular health outcomes, adjusting for sociodemographics, health status, other substance use behaviors, and state-level cannabis laws. State and year fixed effects were also included to adjust for time-invariant state characters and trends in cardiovascular outcomes.</div></div><div><h3>Results</h3><div>The weighted prevalence was 4.4 % for coronary heart disease, 4.5 % for myocardial infarction, 3.6 % for stroke, and 9.3 % for the composite measure of any cardiovascular outcome. Non-daily cannabis use, compared to no cannabis use in the past 30 days, was associated with increased odds of stroke (aOR = 1.28, 95 % CI, 1.06–1.54) and the composite measure (aOR = 1.16, 95 % CI, 1.03–1.29). Daily cannabis use was also associated with increased odds of stroke and the composite measure, with aORs at 1.29 (95 % CI, 1.07–1.54) and 1.20 (95 % CI, 1.06–1.36), respectively. Subgroup analyses revealed that cannabis use was associated with more cardiovascular outcomes among middle-aged adults and females.</div></div><div><h3>Conclusions</h3><div>We found cannabis use to be associated with increased odds of several cardiovascular outcomes. Some population groups who use cannabis, such as middle-aged adults and females, may be at higher cardiovascular risk.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"172 ","pages":"Article 108529"},"PeriodicalIF":4.1000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive behaviors","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306460325002989","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

The effect of cannabis use on cardiovascular disease is mixed in the literature. This study assessed the association between cannabis use and multiple cardiovascular outcomes using recent national data from the U.S. Potential heterogenous effects by age and sex were also examined.

Methods

Using a national sample of 436,949 adults who were interviewed between 2020 and 2023 in BRFSS, we employed multivariable logistic regressions to determine the association between cannabis use and cardiovascular health outcomes, adjusting for sociodemographics, health status, other substance use behaviors, and state-level cannabis laws. State and year fixed effects were also included to adjust for time-invariant state characters and trends in cardiovascular outcomes.

Results

The weighted prevalence was 4.4 % for coronary heart disease, 4.5 % for myocardial infarction, 3.6 % for stroke, and 9.3 % for the composite measure of any cardiovascular outcome. Non-daily cannabis use, compared to no cannabis use in the past 30 days, was associated with increased odds of stroke (aOR = 1.28, 95 % CI, 1.06–1.54) and the composite measure (aOR = 1.16, 95 % CI, 1.03–1.29). Daily cannabis use was also associated with increased odds of stroke and the composite measure, with aORs at 1.29 (95 % CI, 1.07–1.54) and 1.20 (95 % CI, 1.06–1.36), respectively. Subgroup analyses revealed that cannabis use was associated with more cardiovascular outcomes among middle-aged adults and females.

Conclusions

We found cannabis use to be associated with increased odds of several cardiovascular outcomes. Some population groups who use cannabis, such as middle-aged adults and females, may be at higher cardiovascular risk.

查看原文本刊更多论文

2020-2023年美国成年人大麻使用与心血管疾病之间的关系

目的：大麻使用对心血管疾病的影响在文献中是混合的。本研究利用美国最近的国家数据评估了大麻使用与多种心血管结果之间的关系，并研究了年龄和性别的潜在异质性效应。方法：采用BRFSS在2020年至2023年期间采访的436,949名成年人的全国样本，我们采用多变量logistic回归来确定大麻使用与心血管健康结局之间的关系，并调整社会人口统计学、健康状况、其他物质使用行为和州一级大麻法律。还包括状态和年份固定效应，以调整心血管结果的时不变状态特征和趋势。结果：冠心病的加权患病率为4.4%，心肌梗死为4.5%，中风为3.6%，任何心血管结果的综合测量为9.3%。与过去30天内不使用大麻相比，非每日使用大麻与中风的几率增加相关（aOR = 1.28, 95% CI, 1.06-1.54）和综合测量（aOR = 1.16, 95% CI, 1.03-1.29）。每日使用大麻也与中风和综合测量的几率增加有关，aor分别为1.29 （95% CI, 1.07-1.54）和1.20 （95% CI, 1.06-1.36）。亚组分析显示，在中年成年人和女性中，大麻的使用与更多的心血管疾病有关。结论：我们发现大麻的使用与几种心血管结局的几率增加有关。一些使用大麻的人群，如中年人和女性，患心血管疾病的风险可能更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.