Familial Transmission of Major Depression and Bipolar Disorder to Alcohol and Other Drug Use Disorders in a Swedish National Sample: Strongest Effects From Mothers to Daughters.

IF 2.2 3区医学 Q2 PSYCHOLOGY

Journal of studies on alcohol and drugs Pub Date : 2026-05-01 Epub Date: 2025-10-23 DOI:10.15288/jsad.25-00009

Kathryn Polak, Linda Abrahamsson, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler

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引用次数: 0

Abstract

Objective: We investigated the risk for alcohol use disorder (AUD) and drug use disorder (DUD) in the offspring of parents with major depression (MDD) or bipolar disorder (BD), including how parent and offspring sex impact familial transmission.

Method: Offspring born in Sweden during 1970-1990 in intact families with parental MDD or BD (n = 1,218,920) were examined using Swedish population registries. Hazard ratios (HRs) for AUD and DUD risk among offspring were calculated using Cox models.

Results: Offspring of one parent with MDD or BD had higher risks of AUD (HR = 1.34; HR = 1.50, respectively) and DUD (HR = 1.32; HR = 1.43, respectively) than offspring of unaffected parents. Maternal MDD (HR = 1.38) had a stronger effect on offspring DUD than paternal MDD (HR = 1.26), and maternal BD (HR = 1.67) more strongly influenced offspring AUD than paternal BD (HR = 1.34). Parental MDD had stronger effects on daughters than sons for AUD (HR = 1.40 vs. HR = 1.32) and DUD (HR = 1.44 vs. HR = 1.27), whereas no sex differences were found for parental BD. Among daughters, maternal MDD had stronger effects than paternal MDD for AUD (HR = 1.48 vs. 1.32) and DUD (HR = 1.56 vs. 1.33); for sons, maternal MDD had a greater impact on DUD (HR = 1.31 vs. 1.23). Maternal BD had greater effects in daughters, both compared with sons for DUD (HR = 1.92 vs. HR = 1.37) and compared with paternal BD for AUD (HR = 1.82 vs. HR = 1.30) and DUD (HR = 1.92 vs. HR = 1.31).

Conclusions: Findings demonstrate familial transmission of MDD and BD in parents to AUD and DUD in offspring. Affected mothers may be particularly influential. When sex-specific transmission occurred, it was consistently strongest from mother to daughter.

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在瑞典国家样本中，重度抑郁症和双相情感障碍向酒精和其他药物使用障碍的传播：母亲对女儿的最强影响。

目的：研究重度抑郁症（MDD）或双相情感障碍（BD）父母后代酒精使用障碍（AUD）和药物使用障碍（DUD）的风险，包括父母和后代性别对家族传播的影响。方法：使用瑞典人口登记处对1970-1990年在瑞典出生的父母患有重度抑郁症或双相障碍的完整家庭的后代（n=1,218,920）进行检查。使用Cox模型计算后代AUD和DUD风险的风险比（hr）。结果：父母一方患有重度抑郁症或双相障碍的后代患AUD （HR=1.34； HR=1.50）和DUD （HR=1.32； HR=1.43）的风险高于父母未患重度抑郁症或双相障碍的后代。母亲重度抑郁症（HR=1.38）对后代DUD的影响强于父亲重度抑郁症（HR=1.26），母亲双相障碍（HR=1.67）对后代AUD的影响强于父亲双相障碍（HR=1.34）。父母MDD对女儿AUD （HR=1.40 vs. HR=1.32）和DUD （HR=1.44 vs. HR=1.27）的影响强于儿子，而父母BD （HR=1.44 vs. HR=1.27）无性别差异。在女儿中，母亲MDD对AUD （HR=1.48 vs. 1.32）和DUD （HR=1.56 vs. 1.33）的影响强于父亲MDD；对于儿子，母亲重度抑郁症对DUD的影响更大（HR=1.31 vs. 1.23）。母亲双相障碍对女儿的影响大于儿子对DUD的影响（HR=1.92比HR=1.37），而父亲双相障碍对AUD （HR=1.82比HR=1.30）和DUD （HR=1.92比HR=1.31）的影响更大。结论：研究结果表明父母的重度抑郁症和双相障碍遗传给后代的AUD和DUD。受影响的母亲可能特别有影响力。当发生性别特异性传播时，母亲对女儿的传播一直是最强的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of studies on alcohol and drugs 医学-心理学

CiteScore

4.80

自引率

5.90%

发文量

224

审稿时长

3 months

期刊介绍： The Journal of Studies on Alcohol and Drugs began in 1940 as the Quarterly Journal of Studies on Alcohol. It was founded by Howard W. Haggard, M.D., director of Yale University’s Laboratory of Applied Physiology. Dr. Haggard was a physiologist studying the effects of alcohol on the body, and he started the Journal as a way to publish the increasing amount of research on alcohol use, abuse, and treatment that emerged from Yale and other institutions in the years following the repeal of Prohibition in 1933. In addition to original research, the Journal also published abstracts summarizing other published documents dealing with alcohol. At Yale, Dr. Haggard built a large team of alcohol researchers within the Laboratory of Applied Physiology—including E.M. Jellinek, who became managing editor of the Journal in 1941. In 1943, to bring together the various alcohol research projects conducted by the Laboratory, Dr. Haggard formed the Section of Studies on Alcohol, which also became home to the Journal and its editorial staff. In 1950, the Section was renamed the Center of Alcohol Studies.