Preparation of procyanidins-SCP nanoparticles doped in hyaluronic acid-SCP hydrogel with intestinal sustained release to enhance the bioavailability of astaxanthin

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-10-17 DOI:10.1016/j.foodchem.2025.146752

Shasha Huang , Kuiyou Wang , Yi Ma , Zuzhe Wang , Mingqian Tan

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Abstract

Sea cucumber peptide (SCP) reacted with procyanidins and vanillin to form a food-grade nanoparticles (SPNs) via the Mannich reaction. After encapsulation astaxanthin (AXT), the SPNs was attached to a SCP-modified hyaluronic acid (HA) hydrogel to construct AXT@SPNs/HS. The AXT@SPNs/HS exhibited an average size of approximately 1281 nm, while the AXT@SPNs had an average size of 510 nm. The loading capacity of AXT in AXT@SPNs and AXT@SPNs/HS were 6.81 ± 0.10 and 6.56 ± 0.19 μg/mg, respectively. Sustained release of AXT was found during AXT@SPNs/HS digestion and HA-SCP hydrogel provided a significant advantage in protecting AXT in acidic conditions. AXT@SPNs/HS could effectively target RAW264.7 macrophages and mitigated oxidative stress inflammatory response caused by alcohol. AXT@SPNs/HS alleviated acute alcoholic liver damage in mice model. The results illustrated AXT@SPNs/HS might become a candidate with intestinal sustained release to enhance its bioavailability.

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原花青素- scp纳米颗粒掺入透明质酸- scp水凝胶肠道缓释的制备提高虾青素的生物利用度

海参肽（SCP）与原花青素和香兰素通过曼尼希反应形成食品级纳米颗粒（SPNs）。将虾青素（AXT）包封后，将SPNs附着在scp修饰的透明质酸（HA）水凝胶上构建AXT@SPNs/HS。AXT@SPNs/HS的平均尺寸约为1281 nm，而AXT@SPNs的平均尺寸为510 nm。在AXT@SPNs和AXT@SPNs/HS中，AXT的加载量分别为6.81 ± 0.10和6.56 ± 0.19 μg/mg。在AXT@SPNs/HS消化过程中发现AXT的缓释，HA-SCP水凝胶在酸性条件下保护AXT具有显著优势。AXT@SPNs/HS能有效靶向RAW264.7巨噬细胞，减轻酒精引起的氧化应激炎症反应。AXT@SPNs/HS减轻急性酒精性肝损伤小鼠模型。结果表明AXT@SPNs/HS可能成为肠道缓释的候选药物，以提高其生物利用度。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.