A receptor for glycation end products (RAGE) is a key transmitter between garb-aging and inflammaging

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-10-14 DOI:10.1016/j.arr.2025.102919

Zulfiya G. Guvatova , Anna Vakhrusheva , Alexey Moskalev

引用次数: 0

Abstract

A receptor for glycation end products (RAGE) plays a key role in the pathogenesis of many chronic diseases associated with aging. Acting as a multi-ligand sensor, RAGE is able to bind a wide range of stimuli, which fuels inflammation. This makes it a key link between garb-aging and inflammaging. We propose that RAGE functions as the missing molecular link between garb-aging, the progressive buildup of biological waste, and inflammaging, the chronic inflammatory state that drives degenerative disorders. This review summarizes current knowledge on RAGE structure, ligands, and signaling, highlighting its involvement in diabetes, cardiovascular, neurodegenerative, and inflammatory diseases, as well as therapeutic strategies targeting RAGE. By nominating RAGE as a central receptor of garb-aging, we outline new perspectives for combating age-associated pathologies.

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糖基化终产物受体（RAGE）是皮肤老化和炎症之间的关键递质。

糖基化终产物受体（RAGE）在许多与衰老相关的慢性疾病的发病机制中起着关键作用。作为一种多配体传感器，RAGE能够结合广泛的刺激，从而引发炎症。这使得它成为衣服老化和炎症之间的关键环节。我们认为RAGE在衣老化（生物废物的逐渐积累）和炎症（导致退行性疾病的慢性炎症状态）之间起着缺失的分子联系。本文综述了目前关于RAGE结构、配体和信号传导的知识，重点介绍了RAGE在糖尿病、心血管、神经退行性疾病和炎症性疾病中的作用，以及针对RAGE的治疗策略。通过提名RAGE作为服装老化的中心受体，我们概述了对抗年龄相关病理的新视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.