A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium.

IF 6
Life medicine Pub Date : 2025-07-19 eCollection Date: 2025-10-01 DOI:10.1093/lifemedi/lnaf027
Jian Yu, Yankang Zhang, Ting Zhang, Yan Bi, Yan Chen, Zheng Chen, Zhe Dai, Feifan Guo, Lixin Guo, Cheng Hu, Xiangqing Kong, Jian Li, Pingsheng Liu, Yong Liu, Jing Qu, Qiqun Tang, Congyi Wang, Liheng Wang, Jiqiu Wang, Jianping Weng, Aimin Xu, Lingyan Xu, Huijie Zhang, Jiajun Zhao, Jingjing Zhang, Weiqi Zhang, Tongjin Zhao, Weiping Zhang, Zhiming Zhu, Guang-Hui Liu, Guang Ning, Gang Pei, Li Qiang, Feng Liu, Xinran Ma
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引用次数: 0

Abstract

Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.

脂肪组织老化的生物标志物框架:老化生物标志物联盟的共识声明。
脂肪组织是人体重要的能量储存和代谢器官。随着中国老年人口的激增,老年性疾病的预防和管理面临着重大挑战,而脂肪组织老化是多器官衰老的关键启动事件之一。为了应对这些挑战,老龄化中国生物标志物联盟(ABC)通过消化文献和收集科学家和临床医生的见解,建立了关于脂肪组织衰老生物标志物的专家共识。这一共识提供了与脂肪组织衰老相关的关键变化和特征以及生物标志物的全面评估,并提出了将这些生物标志物分类为功能、结构和体液维度的系统框架。在每个维度中,ABC推荐临床和经验验证的生物标志物和参数,用于评估衰老过程中脂肪组织的生理和病理变化,旨在为未来脂肪组织衰老及其相关疾病的预测、诊断、预警和治疗奠定基础,最终达到改善中国和世界老年人脂肪组织健康,促进健康老龄化的目的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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