Dose-response relationship of resistance training and the effects on circulating biomarkers of inflammation or neuroplasticity in older adults: A systematic review and meta-analysis

IF 15.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2026-01-01 Epub Date: 2025-10-12 DOI:10.1016/j.arr.2025.102917

Orgesa Qipo , Guoda Gajauskaitė , Wouter A.J. Vints , Oron Levin , Nerijus Masiulis , Ivan Bautmans

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引用次数: 0

Abstract

Resistance Training (RT) is considered a promising intervention to counteract inflammation and cognitive decline. However, the relationship between RT dose (training duration, frequency, intensity, volume, rest period) and RT-induced changes in circulating biomarkers of inflammation and neuroplasticity remains unclear. The aim of this systematic review and meta-analysis was to determine the overall and dose-response effects of RT on circulating biomarkers of inflammation and neuroplasticity in older adults. Electronic databases (PubMed, Web of Science and Scopus) were systematically screened for relevant studies. The search identified 8306 articles, of which 36 randomized controlled trials (RCTs) were included. Effect sizes (ES) were calculated, and a meta-analysis (RT-effects) and meta-regression (dose-response) were performed when possible. Risk of bias was assessed using the Cochrane Risk of Bias (ROB) 2.0 tool. Meta-analysis showed that RT significantly increased neuroplasticity biomarkers including IGF-1, BDNF, and FGF-21 (ES=0.51, 95 %CI [0.19, 0.84], p = 0.002). Greater improvements were observed with longer training periods (≥20 weeks), a higher number of exercises (≥8), higher weekly training volume and total training program volume, and shorter rest in between exercises (90–120 s). Additionally, RT significantly reduced pro-inflammatory biomarkers including TNF-α, CAF, IL-6, IL-1β, KYN and CRP (ES=-0.66, 95 %CI [-0.80, −0.52], p < 0.001)), with more pronounced effects seen with a higher frequency (at least 3 times per week) and a higher intensity (≥70 % 1RM). Although RT also increased anti-inflammatory biomarkers (IL-10, IL-13, and IL-4, ES=0.75 95 %CI [0.45, 1.04], p < 0.001) the limited number of studies prevented a meta-regression analysis to determine a significant dose-response relationship. These findings demonstrate that RT can significantly improve circulating biomarkers of neuroplasticity and inflammation and highlight key dose-response relationships critical for optimizing RT programs.

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抗阻训练的剂量-反应关系和对老年人炎症或神经可塑性循环生物标志物的影响：一项系统综述和荟萃分析。

抗阻训练（RT）被认为是一种很有前途的干预措施，以抵消炎症和认知能力下降。然而，RT剂量（训练时间、频率、强度、体积、休息时间）与RT诱导的炎症和神经可塑性循环生物标志物变化之间的关系尚不清楚。本系统综述和荟萃分析的目的是确定RT对老年人炎症和神经可塑性循环生物标志物的总体和剂量反应效应。电子数据库（PubMed、Web of Science和Scopus）系统筛选相关研究。检索到8306篇文献，其中包括36项随机对照试验（RCTs）。计算效应量（ES），并在可能的情况下进行meta分析（RT-effects）和meta回归（剂量-反应）。使用Cochrane Risk of bias (ROB) 2.0工具评估偏倚风险。荟萃分析显示，RT显著增加了神经可塑性生物标志物，包括IGF-1、BDNF和FGF-21 （ES=0.51, 95%CI [0.19, 0.84], p=0.002）。较长的训练时间（≥20周）、较高的训练次数（≥8次）、较高的每周训练量和总训练计划量，以及较短的训练间隔休息时间（90-120秒），观察到更大的改善。此外，RT显著降低促炎生物标志物，包括TNF-α、CAF、IL-6、IL-1β、KYN和CRP (ES=-0.66, 95%CI [-0.80, -0.52], p

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.