Evolving Treatment Paradigms of Meningiomas; a Precision Medicine Perspective.

IF 7.4 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2025-10-14 DOI:10.1007/s11910-025-01461-3

Daniela Galluzzo, Casandra Chen, Khaled Alok, Jennifer Moliterno, Sylvia C Kurz

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Abstract

Purpose of review: This review provides a comprehensive overview of the multidisciplinary management strategies available for intracranial meningiomas, with a focus on novel therapies.

Recent findings: With the 2021 WHO classification of tumors of the Central Nervous System (CNS) came the introduction of molecular alterations impacting meningioma grading. As with other central nervous system tumors, the medical management of meningiomas is moving in the direction of targeted therapies. However, meningiomas display significant heterogeneity in their natural history and management options for advanced or recurrent tumor types are lacking. Meningioma management has advanced with refined surgical techniques, radiotherapy strategies, and emerging systemic therapies. Maximal safe resection remains the mainstay of treatment; however, several clinical challenges and unanswered questions persist. Ongoing investigations into targeted therapies and immunotherapies offer promising avenues, particularly for high-grade and recurrent cases.

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脑膜瘤治疗模式的演变精准医学的视角。

综述目的：本文综述了颅内脑膜瘤的多学科治疗策略，重点介绍了新的治疗方法。随着2021年世卫组织中枢神经系统（CNS）肿瘤分类，引入了影响脑膜瘤分级的分子改变。与其他中枢神经系统肿瘤一样，脑膜瘤的医学治疗正朝着靶向治疗的方向发展。然而，脑膜瘤在其自然史上显示出显著的异质性，并且缺乏对晚期或复发肿瘤类型的治疗选择。脑膜瘤的管理随着精细的手术技术、放射治疗策略和新兴的全身治疗而进步。最大限度的安全切除仍然是治疗的主要方法；然而，一些临床挑战和未解决的问题仍然存在。正在进行的靶向治疗和免疫治疗的研究提供了有希望的途径，特别是对于高级和复发病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.