Hierarchical α-zirconium phosphate/reduced graphene oxide nanocomposite for sensitive determination of fleroxacin

IF 4.6 2区农林科学 Q2 CHEMISTRY, APPLIED

Journal of Food Composition and Analysis Pub Date : 2025-10-04 DOI:10.1016/j.jfca.2025.108413

Nanke Ma , Anqi Wei , Yajie Wang , Yafeng Zhang , Yuan Jin , Guangli Li , Xuliang He

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Abstract

The abuse and misuse of fleroxacin (FLE) has led to its concerning accumulation in food and environment, posing potential health risks that demand a rapid, reliable, and sensitive determination method for FLE in complex matrices. Herein, a novel electrochemical sensing platform based on α-zirconium phosphate/reduced graphene oxide (α-ZrP/rGO) nanocomposites was firstly established for sensitive detection of trace FLE residues in tap water and honey. The synergistic interaction between α-ZrP and rGO significantly enhanced the system's electrochemical performance through both enlarged electroactive surface area and accelerated electron transfer kinetics. As a result, the optimized ZrP/rGO modified glassy carbon electrode (GCE) exhibited excellent sensing performance for FLE, with a wide linear response range (0.1 – 10 μM) and a low limit of detection (0.02 μM). In addition, the α-ZrP/rGO/GCE demonstrated high selectivity against potential interferents, and showed good reproducibility and stability (92.12 % response retention after 15 days). Finally, practical applications in real samples yielded satisfactory recoveries of 98.1 % − 103.4 % in tap water and 98.8 % − 104.3 % in honey. These results highlight the potential of α-ZrP/GO nanocomposite as an efficient, reliable platform for real-time, on-site detection of FLE residues in food and environmental matrices.

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分级α-磷酸锆/还原氧化石墨烯纳米复合材料对氟罗沙星的灵敏测定

氟罗沙星（FLE）的滥用和误用导致其在食品和环境中令人担忧的积累，构成潜在的健康风险，需要一种快速、可靠和敏感的复杂基质中FLE测定方法。本文首次建立了基于α-磷酸锆/还原氧化石墨烯（α-ZrP/rGO）纳米复合材料的电化学传感平台，用于自来水和蜂蜜中痕量FLE残留物的灵敏检测。α-ZrP与还原氧化石墨烯之间的协同作用通过增大电活性表面积和加速电子传递动力学显著提高了体系的电化学性能。结果表明，优化后的ZrP/rGO修饰的玻碳电极（GCE）具有较宽的线性响应范围（0.1 ~ 10 μM）和较低的检测限（0.02 μM），具有良好的荧光光谱传感性能。此外，α-ZrP/rGO/GCE对潜在干扰具有较高的选择性，具有良好的重现性和稳定性（15 d后的响应保留率为92.12 %）。最后，在实际样品中的实际应用获得了令人满意的回收率，自来水为98.1% % ~ 103.4 %，蜂蜜为98.8 % ~ 104.3 %。这些结果突出了α-ZrP/GO纳米复合材料作为实时、可靠的现场检测食品和环境基质中FLE残留平台的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Food Composition and Analysis 工程技术-食品科技

CiteScore

6.20

自引率

11.60%

发文量

601

审稿时长

53 days

期刊介绍： The Journal of Food Composition and Analysis publishes manuscripts on scientific aspects of data on the chemical composition of human foods, with particular emphasis on actual data on composition of foods; analytical methods; studies on the manipulation, storage, distribution and use of food composition data; and studies on the statistics, use and distribution of such data and data systems. The Journal''s basis is nutrient composition, with increasing emphasis on bioactive non-nutrient and anti-nutrient components. Papers must provide sufficient description of the food samples, analytical methods, quality control procedures and statistical treatments of the data to permit the end users of the food composition data to evaluate the appropriateness of such data in their projects. The Journal does not publish papers on: microbiological compounds; sensory quality; aromatics/volatiles in food and wine; essential oils; organoleptic characteristics of food; physical properties; or clinical papers and pharmacology-related papers.