Yuge Li, Si Liu, Qian Zhang, Shutian Zhang, Shanshan Wu
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引用次数: 0
Abstract
Background: The novel Dietary Index for Gut Microbiota (DI-GM) quantifies dietary patterns influencing microbiota health, yet its association with irritable bowel syndrome (IBS) risk remains unexplored. We aim to investigate prospective association of DI-GM with incident IBS in a long-term cohort.
Methods: Participants free of IBS at baseline with at least one record of 24-hour dietary recall from UK Biobank were included (N = 175,103). DI-GM was composed of 14 food/nutrient components known to influence gut microbial health. Each component was scored 0 or 1 based on sex-specific median intakes, and total scores were summed. The primary outcome was incident IBS. Multivariable Cox models were used to estimate associated risk.
Results: Over a 12.56-years of follow-up, 2,980 incident IBS cases were identified. Compared to participants with the lowest DI-GM quartile, those with the highest quartile had a 13% lower IBS risk (HR = 0.87; 95% CI: 0.79-0.97; P-value = 0.009), with significant trend (P-trend = 0.012). Moreover, per 1 score increase in DI-GM was associated with a 3% reduced IBS risk (HR = 0.97; 95% CI: 0.95-0.99; P-value = 0.009). Subgroup and sensitivity analyses consistently supported this inverse association.
Conclusions: Higher baseline DI-GM scores, reflecting dietary patterns supportive of gut microbiota, are associated with lower risk of developing IBS. These findings suggest that the DI-GM score may serve as a useful predictive tool for assessing IBS risk and facilitating the implementation of targeted dietary interventions. Future studies should examine changes in DI-GM scores over time help establish a potential causal link with IBS.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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