Bioinspired Nanofluidic Synapse Capable of Dopamine Sensing with an Inverted-U Dose-Response Function.

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2025-10-09 DOI:10.1021/acs.analchem.5c03531

Xian Zhang,Jian-Xiang Pang,Yu-Han Kang,Yi-Feng Wang,Wei-Wei Zhao,Jing-Juan Xu

引用次数: 0

Abstract

In biology, synaptic sensing of neurotransmitter dopamine (DA) has proven to exhibit a characteristic inverted-U shaped dose-response function on cognitive performance and working memory in the prefrontal cortex. With this inspiration, we present a nanofluidic synapse capable of simulating such an intricate behavior by a rationally designed DNA-based DA-responsive nanosensor with good selectivity, reversibility, and stability. The presence of DA could cause gradual DNA collapse and thus regulation of ion flux passing through the nanofluidic synapse, leading to unique DA-mediated hysteresis and synaptic characteristics of an inverted-U manner, based on which artificial neural network-enabled image recognition is done with an inverted-U shaped efficiency and accuracy.

查看原文本刊更多论文

具有倒u型剂量反应函数的生物启发纳米流体突触能够感知多巴胺。

在生物学中，神经递质多巴胺（DA）的突触感应已被证明在前额皮质的认知表现和工作记忆中表现出典型的倒u形剂量反应功能。受此启发，我们提出了一种纳米流体突触，能够通过合理设计的基于dna的da响应纳米传感器来模拟这种复杂的行为，具有良好的选择性，可逆性和稳定性。DA的存在可能导致DNA逐渐崩溃，从而调节通过纳米流体突触的离子通量，导致独特的DA介导的滞后和倒u方式的突触特征，基于此，人工神经网络支持的图像识别以倒u形的效率和准确性完成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.