Modulation of viral neuroinflammation by astrocytic RIPK3 and serine protease inhibitors.

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-10-07 DOI:10.1016/j.tins.2025.09.012

Ebba Rosendal, Anna K Överby

引用次数: 0

Abstract

A recent study by Lindman and colleagues highlights a cell type-specific function of receptor-interacting kinase 3 (RIPK3) in astrocytes during neurotropic flavivirus infection. Despite a proinflammatory transcriptional profile, RIPK3 in astrocytes can attenuate neuroinflammation and reduce leucocyte infiltration through upregulation of Serpin clade A member 3N (SerpinA3N), protecting mice from excessive neuroinflammation and increasing overall survival.

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星形细胞RIPK3和丝氨酸蛋白酶抑制剂对病毒性神经炎症的调节。

Lindman及其同事最近的一项研究强调了在嗜神经黄病毒感染期间星形胶质细胞中受体相互作用激酶3 （RIPK3）的细胞类型特异性功能。尽管具有促炎转录特征，但星形胶质细胞中的RIPK3可以通过上调蛇形蛋白分支a成员3N （SerpinA3N）来减轻神经炎症并减少白细胞浸润，从而保护小鼠免受过度的神经炎症并提高总体存活率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.