Naturaldream brown rice cultivated with deep-sea mineral fertiliser: Integrating sustainable agriculture and functional food science for colorectal cancer prevention

IF 8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Research International Pub Date : 2025-09-26 DOI:10.1016/j.foodres.2025.117626

Nathkapach Kaewpitoon Rattanapitoon , Phatsakul Thitimahatthanakusol , Thawatchai Aeksanti , Schawanya Kaewpitoon Rattanapitoon

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引用次数: 0

Abstract

This correspondence comments on the recent study by Lee et al. (2025) published in Food Research International, which investigated Naturaldream Brown Rice (NBR) cultivated with deep-sea mineral fertiliser for its potential in colorectal cancer (CRC) prevention. NBR demonstrated enriched mineral and γ-oryzanol content, enhanced antioxidant capacity, and significant modulation of pro- and anti-apoptotic markers in in vitro HT-29 colon cancer cells and in vivo AOM/DSS mouse models. The study further revealed potent anti-inflammatory effects and gut microbiota reprogramming towards a eubiotic profile. However, limitations remain regarding the translation of these findings, as rodent AOM/DSS models do not fully recapitulate the complexity of human CRC pathogenesis. Future studies should critically assess human applicability before broad claims are made. These findings highlight NBR as a promising functional food developed through sustainable agriculture, bridging ecological crop production with targeted disease prevention. Moreover, the integration of deep-sea mineral fertiliser should be evaluated not only for nutrient enrichment but also for long-term soil health, carbon footprint reduction, and life-cycle sustainability metrics.

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深海矿物肥料培育的天然梦想糙米：融合可持续农业与功能食品科学，预防大肠癌

这篇通信评论了Lee等人（2025）最近发表在《国际食品研究》（Food Research International）上的一项研究，该研究调查了用深海矿物肥料栽培的天然梦想糙米（NBR）在预防结直肠癌（CRC）方面的潜力。NBR在体外HT-29结肠癌细胞和体内AOM/DSS小鼠模型中显示出丰富的矿物质和γ-谷米醇含量，增强抗氧化能力，并显著调节促凋亡和抗凋亡标志物。该研究进一步揭示了有效的抗炎作用和肠道微生物群向益生菌方向的重编程。然而，这些发现的翻译仍然存在局限性，因为啮齿动物AOM/DSS模型并不能完全概括人类CRC发病机制的复杂性。未来的研究应该在作出广泛的声明之前严格评估人类的适用性。这些研究结果表明，丁腈橡胶是一种有前景的功能性食品，通过可持续农业开发，将生态作物生产与有针对性的疾病预防联系起来。此外，对深海矿物肥料的整合进行评估，不仅要考虑养分的富集，还要考虑长期土壤健康、碳足迹减少和生命周期可持续性指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Research International 工程技术-食品科技

CiteScore

12.50

自引率

7.40%

发文量

1183

审稿时长

79 days

期刊介绍： Food Research International serves as a rapid dissemination platform for significant and impactful research in food science, technology, engineering, and nutrition. The journal focuses on publishing novel, high-quality, and high-impact review papers, original research papers, and letters to the editors across various disciplines in the science and technology of food. Additionally, it follows a policy of publishing special issues on topical and emergent subjects in food research or related areas. Selected, peer-reviewed papers from scientific meetings, workshops, and conferences on the science, technology, and engineering of foods are also featured in special issues.