Trichloroacetic acid in vitiligo management: mechanisms, clinical applications, and future directions.

IF 2.6 4区 医学 Q3 DERMATOLOGY
Ramadan S Hussein, Refaat R Hammad, Shaimaa E Badawy, Salman B Dayel, Othman Abahussein, Huda H Gafar, Abeer A El-Sherbiny, Mofreh Mansour
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引用次数: 0

Abstract

Vitiligo presents a therapeutic challenge due to its unpredictable course and limited treatment options for achieving repigmentation. Trichloroacetic acid (TCA), known for its keratolytic and caustic properties, has emerged as a potential adjunctive therapy in vitiligo management. This review explores the role of TCA alongside established treatment modalities, including phototherapy, topical corticosteroids, and surgical interventions. Mechanisms of action, clinical applications, safety considerations, and future research directions are discussed. TCA acts by inducing controlled chemical injury to the epidermis, facilitating exfoliation and stimulating re-epithelialization. It may also enhance melanocyte migration, proliferation, and pigment production. Combining TCA with phototherapy has shown promise in improving repigmentation rates, while adjunctive use with topical corticosteroids may augment treatment efficacy. In surgical interventions, TCA aids in preparing recipient sites and optimizing graft survival. Adverse effects of TCA include hyperpigmentation and scarring, necessitating careful patient selection and monitoring. Future research should focus on optimizing TCA protocols, conducting large-scale clinical trials, and exploring novel therapeutic combinations. Overall, TCA holds potential as a valuable adjunctive therapy in the multifaceted approach to vitiligo treatment, offering hope for improved outcomes in affected individuals.

三氯乙酸在白癜风治疗中的作用:机制、临床应用及未来发展方向。
白癜风提出了一个治疗挑战,由于其不可预测的过程和有限的治疗方案,以实现重新着色。三氯乙酸(TCA)以其角化和腐蚀性而闻名,已成为白癜风治疗的潜在辅助疗法。这篇综述探讨了TCA与现有治疗方式的作用,包括光疗、局部皮质类固醇和手术干预。对其作用机制、临床应用、安全性及未来研究方向进行了讨论。TCA的作用是诱导可控的表皮化学损伤,促进表皮脱落和刺激表皮再生。它还可以促进黑素细胞的迁移、增殖和色素的产生。将TCA与光疗相结合可以改善色素重沉着率,而局部皮质类固醇的辅助使用可以提高治疗效果。在外科干预中,TCA有助于准备受体部位和优化移植物存活。TCA的副作用包括色素沉着和疤痕,需要仔细选择和监测患者。未来的研究应侧重于优化TCA方案,开展大规模临床试验,探索新的治疗组合。总的来说,TCA在白癜风治疗的多方面方法中具有潜在的有价值的辅助治疗,为改善受影响个体的预后提供了希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
442
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