Manipulation of Electrochemical Enantioselective Sensing of Chiral Metal Organic Frameworks Using the Charge Reconstruction Strategy.

Abstract

The surface charge state has a significant effect on the process of chiral recognition. Charged surfaces can selectively adsorb specific chiral molecules through electrostatic interactions. Herein, the surface charge state of coordination polymer particles (CPPs) was transformed from negative to positive by changing the dosage of acetic acid. By combination of the chiral properties of zirconium-based metal-organic frameworks (L-PCN-224) with the surface advantages of oppositely charged CPP-1 and CPP-5 (CPP-1@L-PCN-224 and CPP-5@L-PCN-224), a chiral composite material with oppositely charged surfaces has been constructed. Systematic studies indicate that the polarity of surface charges under varying pH conditions significantly influences the selective adsorption of tryptophan (Trp) enantiomers. Our findings reveal a clear structure-property relationship between the charge polarity and chiral recognition performance in chiral metal-organic frameworks (CMOFs), offering an alternative approach to traditional chiral site-dependent materials. This study reveals the correlation between the altered charge polarity of CMOFs and their chiral recognition properties, offering an alternative to conventional materials. This study focuses on the transformation patterns of supramolecular interactions driven by charge alterations in materials under specific pH conditions. While grounded in conventional paradigms, it elucidates the role of charge polarity in determining dominant interaction types, offering novel insights into traditional chiral recognition.