Lactiplantibacillus plantarum: a Natural Ally in Combating Type 2 Diabetes Mellitus and Related Metabolic Disorders.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2025-09-30 DOI:10.1007/s12602-025-10729-6

Wenqi Wu, Zhibin Wang, Lina Ding, Yikun Zhang, Kaihui Ma, Hongsheng Li, Yanli Hou, Wenyu Ding

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Abstract

This review investigates the mechanisms, functional roles, and therapeutic potential of Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum) in type 2 diabetes mellitus (T2DM) and its associated metabolic disorders. As a widely recognized probiotic species due to its widespread use in food processing and as a natural inhabitant of human and animal gastrointestinal tracts, Lactiplantibacillus plantarum has garnered significant attention for its potential in metabolic regulation. Specifically, this study focuses on its capacities to alleviate insulin resistance, restore insulin secretion, and ameliorate dyslipidemia, among other metabolic disturbances. The mechanisms underlying Lactiplantibacillus plantarum's beneficial effects on lipid and glucose metabolism are multifactorial, including modulation of gut microbiota composition, restoration of intestinal barrier function, mitigation of systemic inflammation, and potentiation of metabolic regulatory pathways. Notably, Lactiplantibacillus plantarum achieves these effects by regulating glycolytic and lipid biosynthesis, modulating intestinal hormone signaling, and influencing cholesterol and fatty acid metabolism. These findings underscore the potential of Lactiplantibacillus plantarum as a probiotic agent in the treatment of T2DM and related disorders. However, to fully harness its therapeutic potential, further studies are required to validate its safety and efficacy in diverse clinical settings.

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植物乳杆菌：对抗2型糖尿病及相关代谢紊乱的天然盟友。

本文综述了植物乳杆菌（以前称为植物乳杆菌）在2型糖尿病（T2DM）及其相关代谢紊乱中的作用机制、功能作用和治疗潜力。植物乳杆菌作为一种被广泛认可的益生菌物种，由于其在食品加工中的广泛应用，以及作为人类和动物胃肠道的天然居民，植物乳杆菌因其代谢调节的潜力而引起了人们的广泛关注。具体而言，本研究侧重于其缓解胰岛素抵抗，恢复胰岛素分泌，改善血脂异常等代谢紊乱的能力。植物乳杆菌对脂质和糖代谢的有益作用的机制是多因素的，包括调节肠道菌群组成、恢复肠道屏障功能、减轻全身炎症和增强代谢调节途径。值得注意的是，植物乳杆菌通过调节糖酵解和脂质生物合成、调节肠道激素信号以及影响胆固醇和脂肪酸代谢来实现这些作用。这些发现强调了植物乳杆菌作为一种益生菌制剂治疗2型糖尿病和相关疾病的潜力。然而，为了充分利用其治疗潜力，需要进一步的研究来验证其在不同临床环境中的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.