Cross-sectional analyses between the dietary index for gut microbiota and Parkinson's disease in the middle-aged and elderly population.

IF 3.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-09-30 DOI:10.1186/s12937-025-01206-5

Yiming Zhan, Yuhang Liu, Huxingzi Liu, Siyao Gao, Jialing Tang

{"title":"Cross-sectional analyses between the dietary index for gut microbiota and Parkinson's disease in the middle-aged and elderly population.","authors":"Yiming Zhan, Yuhang Liu, Huxingzi Liu, Siyao Gao, Jialing Tang","doi":"10.1186/s12937-025-01206-5","DOIUrl":null,"url":null,"abstract":"Background: The evidence linking dietary indices to Parkinson's disease (PD) risk remains limited. This study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and PD risk in middle-aged and elderly populations.Methods: Cross-sectional data were obtained from the 2007-2020 cycles of the National Health and Nutrition Examination Survey (NHANES), including 17,373 participants aged 40 years or older. PD was defined by antiparkinsonian medication use. DI-GM scores were calculated based on 14 dietary components. Multiple logistic regression and a restricted cubic spline model (RCS) were used to test the relationship between DI-GM and PD. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the results.Results: Among 17,373 participants, those with PD (n = 232) had lower DI-GM scores compared to non-PD individuals. Higher DI-GM scores (≥ 6) were associated with a 49% reduction in PD prevalence. RCS analysis showed a non-linear relationship between DI-GM and PD (P < 0.05). Subgroup and sensitivity analyses confirmed stable associations across demographic groups and after adjusting for comorbidities.Conclusions: A gut microbiota-friendly diet, as measured by DI-GM, is associated with reduced PD risk, especially in the higher DI-GM score. This finding may inform future dietary guidelines for the prevention of PD.","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"138"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481752/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12937-025-01206-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The evidence linking dietary indices to Parkinson's disease (PD) risk remains limited. This study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and PD risk in middle-aged and elderly populations.

Methods: Cross-sectional data were obtained from the 2007-2020 cycles of the National Health and Nutrition Examination Survey (NHANES), including 17,373 participants aged 40 years or older. PD was defined by antiparkinsonian medication use. DI-GM scores were calculated based on 14 dietary components. Multiple logistic regression and a restricted cubic spline model (RCS) were used to test the relationship between DI-GM and PD. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the results.

Results: Among 17,373 participants, those with PD (n = 232) had lower DI-GM scores compared to non-PD individuals. Higher DI-GM scores (≥ 6) were associated with a 49% reduction in PD prevalence. RCS analysis showed a non-linear relationship between DI-GM and PD (P < 0.05). Subgroup and sensitivity analyses confirmed stable associations across demographic groups and after adjusting for comorbidities.

Conclusions: A gut microbiota-friendly diet, as measured by DI-GM, is associated with reduced PD risk, especially in the higher DI-GM score. This finding may inform future dietary guidelines for the prevention of PD.

查看原文本刊更多论文

中老年人群肠道菌群饮食指数与帕金森病的横断面分析

背景：将饮食指标与帕金森病（PD）风险联系起来的证据仍然有限。本研究探讨了中老年人群肠道微生物群膳食指数（DI-GM）与PD风险的关系。方法：从2007-2020年周期的国家健康与营养检查调查（NHANES）中获得横断面数据，包括17373名40岁及以上的参与者。PD的定义是使用抗帕金森药物。根据14种膳食成分计算DI-GM评分。采用多元逻辑回归和限制三次样条模型（RCS）检验DI-GM与PD之间的关系。进行亚组分析和敏感性分析以评价结果的稳健性。结果：在17373名参与者中，PD患者（n = 232）的DI-GM评分低于非PD患者。较高的DI-GM评分（≥6）与PD患病率降低49%相关。RCS分析显示DI-GM与PD之间存在非线性关系(P结论：肠道微生物友好型饮食，以DI-GM衡量，与PD风险降低相关，特别是在DI-GM评分较高的情况下。这一发现可能为未来预防PD的饮食指南提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.