PIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma.

IF 2 4区生物学 Q3 CELL BIOLOGY

Histology and histopathology Pub Date : 2025-09-30 DOI:10.14670/HH-18-996

Szu-Chi Yao, Hung-Chang Wu, Ching-Chieh Yang, Yun-Tzu Lin, Chien-Feng Li, Shih-Lun Chang, Yu-Hsuan Kuo

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引用次数: 0

Abstract

Background: Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with metastasis and recurrence leading to poor prognosis. Identifying prognostic biomarkers is essential.

Methods: We analyzed differentially expressed genes involved in the phosphatidylinositol metabolic process (GO: 0046488) and tumorigenesis (GSE12452) in NPC. Associations between PIP5K3 expression and clinicopathological features were assessed using chi-square tests and Cox proportional hazards models.

Results: PIP5K3 was significantly upregulated in NPC tissues, correlating with advanced stage (p=0.001) and nodal metastasis (p<0.001). High PIP5K3 expression was associated with worse disease-specific survival (DSS), distant metastasis-free survival (DMeFS), and local recurrence-free survival (LRFS). Multivariate analysis confirmed its association with poor prognosis (DSS: HR=4.321, DMeFS: HR=2.883, LRFS: HR=2.249; all p<0.001).

Conclusions: PIP5K3 upregulation is associated with unfavorable clinical outcomes in NPC and may serve as a novel prognostic biomarker and potential therapeutic target.

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PIP5K3表达上调与鼻咽癌患者预后不良相关

背景：鼻咽癌（NPC）常见于东亚和东南亚地区，其转移和复发导致预后不良。确定预后生物标志物至关重要。方法：我们分析了鼻咽癌中参与磷脂酰肌醇代谢过程（GO: 0046488）和肿瘤发生（GSE12452）的差异表达基因。使用卡方检验和Cox比例风险模型评估PIP5K3表达与临床病理特征之间的关系。结果：PIP5K3在鼻咽癌组织中显著上调，与鼻咽癌晚期（p=0.001）和淋巴结转移相关。结论：PIP5K3上调与鼻咽癌的不良临床结局相关，可能作为一种新的预后生物标志物和潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histology and histopathology 生物-病理学

CiteScore

3.90

自引率

0.00%

发文量

232

审稿时长

2 months

期刊介绍： HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.