Neuronal Plasticity in the Mushroom Bodies of Winter Bees Is Retained Despite Substantially Advanced Age

IF 2.3 4区 医学 Q2 DEVELOPMENTAL BIOLOGY
Nadine Kraft, Wolfgang Rössler, Claudia Groh
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引用次数: 0

Abstract

Honeybee (Apis mellifera) workers exhibit remarkable behavioral plasticity throughout adult life. In spring and summer, they transition through diverse tasks over a short lifespan of 4–6 weeks. This involves dramatic changes in sensory environment and cognitive demands associated with pronounced structural neuronal plasticity in the mushroom bodies (MBs), high-order brain centers for sensory integration, learning, and memory. This plasticity manifests as age- and experience-related volume increase in sensory input regions of the MB calyces, accompanied by pruning of projection neuron (PN) boutons in synaptic microcircuits within visual and olfactory compartments. As winter approaches, honeybees suspend brood rearing and foraging activities to survive the cold months by forming a tight, thermoregulated cluster. Unique physiological adaptations enable winter bees to live up to 8 months until a new generation emerges in spring. This extended lifespan occurs during a period of reduced sensory input and high metabolic costs raising the question of how such conditions affect structural neuronal plasticity. Using synapsin immunolabeling and 3D confocal-microscopy image analyses of MB synaptic neuropils in whole-mount brains of age-controlled worker bees, we found that winter bees retain a high degree of neuronal plasticity throughout their lifespan. MB calyces exhibit an initial volume increase followed by a period of stagnation to then undergo another expansion at the onset of spring foraging. While olfactory PN boutons exhibit continuous pruning, visual bouton numbers remain stable during winter. We conclude that winter bees retain comparable neuronal capacities to summer bees, despite strong differences in lifespan, physiological, and environmental conditions.

尽管年事已高,但冬蜂蘑菇体的神经元可塑性仍保持不变。
蜜蜂(Apis mellifera)工蜂在整个成年生活中表现出显著的行为可塑性。在春季和夏季,它们在4-6周的短暂生命中转换各种任务。这涉及到感觉环境和认知需求的巨大变化,这些变化与蘑菇体(mb)中显著的结构神经元可塑性有关,蘑菇体是负责感觉整合、学习和记忆的高阶大脑中心。这种可塑性表现为与年龄和经验相关的MB花萼感觉输入区域的体积增加,伴随着视觉和嗅觉室突触微回路中投射神经元(PN)扣的修剪。随着冬天的临近,蜜蜂暂停哺育后代和觅食活动,通过形成一个紧密的、温度调节的集群来度过寒冷的月份。独特的生理适应使冬季蜜蜂能够存活长达8个月,直到新一代在春天出现。这种延长的寿命发生在感觉输入减少和代谢成本高的时期,这就提出了这样的条件如何影响结构神经元可塑性的问题。通过突触免疫标记和三维共聚焦显微镜对工蜂全脑MB突触神经粒的图像分析,我们发现冬蜂在其整个生命周期中保持了高度的神经元可塑性。MB花萼表现出最初的体积增加,随后是一段停滞期,然后在春季觅食开始时再次扩大。而嗅觉PN钮扣表现出连续修剪,视觉钮扣数量在冬季保持稳定。我们的结论是,尽管冬季蜜蜂的寿命、生理和环境条件存在很大差异,但它们与夏季蜜蜂保持着相当的神经元能力。
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来源期刊
Developmental Neurobiology
Developmental Neurobiology 生物-发育生物学
CiteScore
6.50
自引率
0.00%
发文量
45
审稿时长
4-8 weeks
期刊介绍: Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.
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