Heatstroke Is Associated with an Increased Risk of Chronic Headache: A Retrospective Cohort Study.

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Karel Kostev, Ira Rodemer, Marcel Konrad, Jens Bohlken
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Abstract

Background: Heatstroke is the most severe form of heat-related illness. It is characterized by an elevated core body temperature and central nervous system dysfunction. The aim of this study was to investigate the association between heatstroke and subsequent migraine development.

Methods: This retrospective cohort study used data from the Disease Analyzer database (IQVIA) and included individuals diagnosed with heatstroke, as well as propensity score-matched individuals without heatstroke. Data about these individuals was recorded in 1216 general practices in Germany between January 2005 and December 2023. Five-year cumulative migraine incidence was assessed using Kaplan-Meiercurves, and univariable Cox regression analysis was performed to evaluate the association between heatstroke and migraine.

Results: The study included 5794 individuals with heatstroke and 28,970 matched controls without heatstroke (median age: 30 years, 31-32% female). Most heatstroke cases were documented in June (32-34%), followed by July (30%), August (15-17%), and May (13%). Within five years of follow-up, 8.8% of patients with heatstroke and 4.0% of controls were diagnosed with migraine. The regression analysis revealed that heatstroke was significantly associated with an increased risk of migraine in the total population (HR: 2.26; 95% CI: 2.00-2.57), as well as in women (HR: 2.33; 95% CI: 1.96-2.79) and men (HR: 2.26; 95% CI: 1.89-2.70).

Conclusion: This study highlights an important, yet previously underrecognized, association between heatstroke and an increased risk of migraine. As global temperatures continue to rise, public health strategies should focus not only on the acute prevention and management of heat-related illnesses, but also on their potential long-term neurological consequences.

中暑与慢性头痛风险增加有关:一项回顾性队列研究
背景:中暑是最严重的热相关疾病。它的特点是核心体温升高和中枢神经系统功能障碍。这项研究的目的是调查中暑和随后偏头痛发展之间的关系。方法:本回顾性队列研究使用来自疾病分析数据库(IQVIA)的数据,包括诊断为中暑的个体,以及倾向评分匹配的无中暑个体。在2005年1月至2023年12月期间,这些个体的数据被记录在德国的1216个一般实践中。采用kaplan - meier曲线评估5年累积偏头痛发病率,并采用单变量Cox回归分析评估中暑与偏头痛之间的关系。结果:该研究包括5794例中暑患者和28970例无中暑对照(中位年龄:30岁,31-32%为女性)。大多数中暑病例发生在6月(32-34%),其次是7月(30%)、8月(15-17%)和5月(13%)。在5年的随访中,8.8%的中暑患者和4.0%的对照组被诊断为偏头痛。回归分析显示,在总人口中,中暑与偏头痛风险增加显著相关(HR: 2.26; 95% CI: 2.00-2.57),女性(HR: 2.33; 95% CI: 1.96-2.79)和男性(HR: 2.26; 95% CI: 1.89-2.70)。结论:这项研究强调了中暑和偏头痛风险增加之间一个重要的,但以前未被认识到的关联。随着全球气温持续上升,公共卫生战略不仅应关注与热有关的疾病的急性预防和管理,还应关注其潜在的长期神经后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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