Navigating a Misty Road: Novel Ways to Study the Impact of Cognition on Driving Performance in Multiple Sclerosis.

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Ioannis Nikolakakis, Panagiotis Grigoriadis, Nefeli Dimitriou, Dimitrios Parisis, Grigorios Nasios, Lambros Messinis, Christos Bakirtzis
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引用次数: 0

Abstract

Background/Objectives: The ability to drive is closely linked to participation in daily activities and quality of life in people living with neurological disorders. Cognitive deficits in people with multiple sclerosis (pwMS) are known to hinder this ability, yet concrete fitness-to-drive criteria remain elusive and assessment guidelines lack uniformity. A plethora of cognitive tests have provided associations with various aspects of driving performance and on-road behavior; however, several studies reveal limitations and inconsistencies in most tests' sensitivity and predictive effect. Novel and resurfaced modalities for cognitive assessment, in the form of advanced imaging techniques and electrophysiological studies, may offer improved sensitivity in driving-related abilities in earlier and milder stages. Their application in addition to evaluations in driving simulators may aid future research and enhance the quality of evidence to inform decision-making. Methods: We searched for the relevant literature in the PubMed database and synthesized the available findings for the applications of currently clinically used cognitive tests, markers derived from functional magnetic resonance imaging (fMRI) and diffuse tensor imaging (DTI), as well as event-related potentials (ERP). Results: Advanced imaging modalities and ERP studies may better capture neurobiological changes that lead to driving impairment in pwMS, and they may also be applied to detect cognitive alterations earlier and with greater precision, helping to predict driving difficulties in this population. Conclusions: Novel tools and driving simulator settings could improve our understanding of the relation between cognition and driving in pwMS, enhance protocol homogeneity in driving studies, and aid in the formation of guidelines. The evidence in this review supports an increase in their application in future studies.

在雾蒙蒙的道路上航行:研究认知对多发性硬化症驾驶性能影响的新方法。
背景/目的:神经系统疾病患者的驾驶能力与日常活动的参与和生活质量密切相关。众所周知,多发性硬化症(pwMS)患者的认知缺陷会阻碍这种能力,但具体的健康驾驶标准仍然难以捉摸,评估指南也缺乏一致性。大量的认知测试提供了与驾驶性能和道路行为的各个方面的联系;然而,一些研究揭示了大多数测试的敏感性和预测效果的局限性和不一致性。以先进的成像技术和电生理研究为形式,新的和重新出现的认知评估模式可能会在早期和轻度阶段提高驾驶相关能力的敏感性。除了驾驶模拟器的评估外,它们的应用可能有助于未来的研究,并提高决策的证据质量。方法:我们在PubMed数据库中检索相关文献,并综合目前临床使用的认知测试、功能磁共振成像(fMRI)和弥散张量成像(DTI)产生的标记物以及事件相关电位(ERP)的可用发现。结果:先进的成像模式和ERP研究可以更好地捕捉导致pwMS驾驶障碍的神经生物学变化,它们也可以更早、更精确地检测认知改变,帮助预测这一人群的驾驶困难。结论:新的工具和驾驶模拟器设置可以提高我们对pwMS认知与驾驶之间关系的理解,增强驾驶研究中的协议同质性,并有助于指南的形成。本综述中的证据支持在未来的研究中增加它们的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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