Multiplexed detection of refractive indices among analytes via microfluidics and optical ring resonator: Optical coupling approach

Abstract

The presented work examines the detection of multiple biological analytes associated with various diseases in humans using an optical ring resonator-based refractive index sensor. The suggested sensor has great potential in the healthcare domain for early disease diagnosis. The sensor system, utilizing a C-band (1550 nm) optical source, has been designed and numerically analyzed to detect sickle cell anemia (SCA), breast cancer cells, glucose concentrations, and tuberculosis. The time-efficient finite different time domain (FDTD) method has been employed to optimize the performance metrics of the sensor enhancing the sensitivity ($S$), figure of merit ($FOM$), and quality factor ($QF$). Apparently, the designed sensor can detect multiple analytes with $S=420.45$ nanometer/Refractive Index Unit (nm/RIU), $FOM=289.85$ RIU^-1, and $QF=1107.36$, respectively. The obtained results further motivates the fabrication of ubiquitous sensing system for multiple disease detection.