Self-nanoemulsifying delivery system of PEITC ameliorates DSS-induced ulcerative colitis by regulating NF-κB pathway, modulating oxidative stress, and barrier repair

IF 5.9 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-09-23 DOI:10.1016/j.fbio.2025.107649

Haibo Huang , Changlong Ouyang , Haoxi Ma , Ping Tang , Zijun Wang , Yiyang Hou , Lijuan Zhu , Xiaojing Ma

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Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that significantly affects patients' quality of life. Although Phenethyl isothiocyanate (PEITC) has shown considerable promise in alleviating intestinal inflammation, the low bioavailability and water insolubility have hindered further development and clinical application. In this study, a self-assembled nanoemulsion (PNE) was successfully developed, and its physicochemical properties and therapeutic efficacy against UC were systematically evaluated. The prepared nanoemulsions displayed excellent stability, anti-inflammatory, and antioxidant activities. In dextran sulfate sodium (DSS)-induced colitis in mice, treatment with PNE significantly alleviated weight loss, restored colon length, reduced DAI score, and mitigated histopathological damage. These therapeutic effects may be attributed to PEITC's ability to attenuate intestinal oxidative stress, suppress inflammatory responses, and enhance the integrity of the intestinal barrier. In conclusion, the results of this study indicate that PNE holds therapeutic potential in the treatment of UC and lays the groundwork for future clinical applications.

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PEITC自纳米乳化递送系统通过调节NF-κB通路、调节氧化应激和屏障修复改善dss诱导的溃疡性结肠炎

溃疡性结肠炎（UC）是一种慢性炎症性肠病，严重影响患者的生活质量。尽管异硫氰酸苯乙酯（PEITC）在缓解肠道炎症方面显示出相当大的前景，但其低生物利用度和不水溶性阻碍了其进一步的开发和临床应用。本研究成功制备了一种自组装纳米乳（PNE），并对其理化性质和治疗UC的疗效进行了系统评价。制备的纳米乳具有良好的稳定性、抗炎和抗氧化活性。在葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎中，PNE治疗可显著减轻体重减轻，恢复结肠长度，降低DAI评分，减轻组织病理学损伤。这些治疗效果可能归因于PEITC减轻肠道氧化应激、抑制炎症反应和增强肠道屏障完整性的能力。总之，本研究结果表明PNE在UC治疗中具有治疗潜力，为未来的临床应用奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.