Reactivity to electronic nicotine delivery system (ENDS) cues in adults who smoke cigarettes and vape cannabis

IF 3.6 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2025-09-24 DOI:10.1016/j.addbeh.2025.108502

Krista Miloslavich , Emma I. Brett , Daniel J. Fridberg , Andrea C. King

{"title":"Reactivity to electronic nicotine delivery system (ENDS) cues in adults who smoke cigarettes and vape cannabis","authors":"Krista Miloslavich , Emma I. Brett , Daniel J. Fridberg , Andrea C. King","doi":"10.1016/j.addbeh.2025.108502","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Prior research shows that in-person exposure to electronic nicotine delivery systems (ENDS) use increases desire for both cigarettes and ENDS. Distinct from nicotine ENDS use, cannabis vaping is on the rise, often in conjunction with nicotine vaping or combustible cigarettes, marking a need to understand how co-use impacts ENDS cue reactivity. This study leverages a remote cue-delivery paradigm to evaluate the impact of co-use of cigarettes and cannabis on reactivity to a remote ENDS cue.</div></div><div><h3>Methods</h3><div>A cannabis co-use group (N = 45, individuals who smoke cigarettes and vape cannabis) and a non-co-use group (n = 61, individuals who smoke cigarettes and do not vape cannabis) observed a study confederate drinking bottled water (control cue) and vaping an ENDS (active cue). Desire to use a cigarette, ENDS and cannabis were measured before the cues (baseline), post-water and post-ENDS cue.</div></div><div><h3>Results</h3><div>Multilevel models, controlling for sex and weekly ENDS use, examined cue reactivity across the co-use and non-co-use groups. Those who vaped cannabis in the past year reported both higher baseline ENDS and cannabis desire and heightened responses to the ENDS cue such that cue exposure significantly increased their desire for cigarettes, ENDS and cannabis.</div></div><div><h3>Conclusions</h3><div>This study provides the first evidence for differential ENDS cue-elicited desire in those who smoke cigarettes and vape cannabis. These findings suggest that co-use of cannabis and cigarettes may increase vulnerability to cravings, indicating a need for tailored prevention and intervention strategies for individuals who use both substances.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"172 ","pages":"Article 108502"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive behaviors","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306460325002631","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Prior research shows that in-person exposure to electronic nicotine delivery systems (ENDS) use increases desire for both cigarettes and ENDS. Distinct from nicotine ENDS use, cannabis vaping is on the rise, often in conjunction with nicotine vaping or combustible cigarettes, marking a need to understand how co-use impacts ENDS cue reactivity. This study leverages a remote cue-delivery paradigm to evaluate the impact of co-use of cigarettes and cannabis on reactivity to a remote ENDS cue.

Methods

A cannabis co-use group (N = 45, individuals who smoke cigarettes and vape cannabis) and a non-co-use group (n = 61, individuals who smoke cigarettes and do not vape cannabis) observed a study confederate drinking bottled water (control cue) and vaping an ENDS (active cue). Desire to use a cigarette, ENDS and cannabis were measured before the cues (baseline), post-water and post-ENDS cue.

Results

Multilevel models, controlling for sex and weekly ENDS use, examined cue reactivity across the co-use and non-co-use groups. Those who vaped cannabis in the past year reported both higher baseline ENDS and cannabis desire and heightened responses to the ENDS cue such that cue exposure significantly increased their desire for cigarettes, ENDS and cannabis.

Conclusions

This study provides the first evidence for differential ENDS cue-elicited desire in those who smoke cigarettes and vape cannabis. These findings suggest that co-use of cannabis and cigarettes may increase vulnerability to cravings, indicating a need for tailored prevention and intervention strategies for individuals who use both substances.

查看原文本刊更多论文

吸烟和吸电子大麻的成年人对电子尼古丁传递系统（ENDS）信号的反应。

先前的研究表明，接触电子尼古丁传递系统（ENDS）会增加对香烟和电子尼古丁传递系统的渴望。与尼古丁终端的使用不同，大麻电子烟的使用正在增加，通常与尼古丁电子烟或可燃香烟一起使用，这表明有必要了解共同使用如何影响终端的线索反应。本研究利用远程线索传递范式来评估香烟和大麻共同使用对远程ENDS线索反应性的影响。方法：大麻共同使用组（N = 45，吸烟和吸电子烟的人）和非共同使用组（N = 61，吸烟但不吸电子烟的人）观察了一项研究，该研究将饮用瓶装水（对照线索）和吸电子烟（主动线索）联系起来。使用香烟、ENDS和大麻的欲望在提示前（基线）、喝水后和ENDS提示后被测量。结果：多层模型，控制性别和每周终端使用，检查提示反应在共同使用和非共同使用组。那些在过去一年中吸过大麻的人报告了更高的基线ENDS和大麻欲望，并且对ENDS提示的反应增强，因此暗示暴露显着增加了他们对香烟、ENDS和大麻的渴望。结论：本研究提供了首个证据，证明ENDS线索在吸烟和吸电子大麻人群中引发的欲望不同。这些发现表明，同时使用大麻和香烟可能会增加对渴望的脆弱性，这表明需要为同时使用这两种物质的个人制定量身定制的预防和干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.