The Role of Nucleotide Sequencing in Natural Product Drug Discovery.

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-09-25 DOI:10.1021/acs.jnatprod.5c00876

Samantha C Waterworth

引用次数: 0

Abstract

For millennia, humans have drawn upon natural sources for medicinal remedies. However, the discovery process was often a serendipitous endeavor, and the true biosynthetic potential of the planet's biodiversity remained largely hidden. The advent of nucleotide sequencing offered a pivotal shift, providing tools to decipher the cryptic codes within biosynthetic machinery. In this Perspective, I describe the arc of the sequencing era, from its foundational impact to the current landscape of sophisticated bioinformatic tools. Furthermore, I will address the international legal frameworks being implemented to protect the very biodiversity upon which the field of natural product discovery relies.

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核苷酸测序在天然产物药物发现中的作用。

几千年来，人类一直在利用自然资源进行药物治疗。然而，发现过程往往是一种偶然的努力，而地球生物多样性的真正生物合成潜力在很大程度上仍然被隐藏。核苷酸测序的出现提供了一个关键的转变，提供了破译生物合成机器中神秘密码的工具。在这个视角中，我描述了测序时代的弧线，从其基础影响到复杂生物信息学工具的当前景观。此外，我将谈到为保护天然产物发现领域所依赖的生物多样性而实施的国际法律框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.