Actinomycetoquinones A-E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived Actinomycetospora sp. Bacterium.

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-09-25 DOI:10.1021/acs.jnatprod.5c00578

Fan Zhang, Christopher D Roberts, Tae Hyun Lee, Doug R Braun, Zachary D Bennett, Shaurya Chanana, Song Guo, Gene E Ananiev, Ilia A Guzei, Scott R Rajski, Thomas C Brunold, Tim S Bugni

引用次数: 0

Abstract

Facilitated by LC-MS-PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A-E (1-5), were isolated from a marine-derived Actinomycetospora sp. bacterium. The structures of 1-5 were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Actinomycetoquinone C exhibited antibacterial activity against methicillin-resistant S. aureus (MRSA) and E. coli with MIC values of 1 and 4 μg/mL, respectively.

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从海洋源放线菌孢子菌中发现放线菌醌A-E、蒽醌γ- pyroones。

利用LC-MS-PCA代谢组学方法和有效的分子网络对菌株进行优先排序和分离，从一株海洋来源的放线菌胞醌a - e（1-5）中分离到5个新的蒽醌-γ- pyroones。通过HRMS和NMR数据分析，对1 ~ 5个化合物的结构进行了鉴定。用Cu Kα辐射单晶x射线衍射分析明确了1的绝对构型。放线菌醌C对耐甲氧西林金黄色葡萄球菌（MRSA）和大肠杆菌具有抗菌活性，MIC值分别为1和4 μg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.