Development of dual-dummy template molecularly imprinted polymer embedded with Ag nanoparticles for sensitive and selective detection of fumonisin B1 using surface-enhanced Raman spectroscopy

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-09-26 DOI:10.1016/j.foodchem.2025.146561

Wenlei Zhai, Mingshuo Cao, Dizhe Wei, Yuan Wang, Meng Wang

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引用次数: 0

Abstract

Fumonisin B1 (FB1) is the most toxic and common form of fumonisins. Exposure to FB1 can lead to various harmful effects on human and livestock health. Herein, an FB1 sensor was developed by combining molecularly imprinted polymer (MIP) technique with surface-enhanced Raman spectroscopy (SERS). A dual-dummy template strategy was developed for MIP synthesis by employing succinic acid and d-sphingosine as the analogs of FB1. The MIP-SERS method was established based on a sensor composed of Ag nanoparticles encapsulated by the MIP. Signal amplification was achieved through the competitive displacement of the Raman tag by FB1. SERS detection of FB1 with a detection limit of 15 ng mL⁻¹ was achieved. Detecting FB1 in cereals was demonstrated via spiked and real sample measurements, with recovery rates of 89.2 % – 120.2 %. This study demonstrated the synthesis of MIP using the dual-dummy template strategy and its application in the rapid detection of FB1.

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纳米银包埋双假模板分子印迹聚合物表面增强拉曼光谱灵敏和选择性检测伏马菌素B1

伏马菌素B1 （FB1）是最毒和最常见的伏马菌素形式。接触FB1可对人类和牲畜健康造成各种有害影响。本文将分子印迹聚合物（MIP）技术与表面增强拉曼光谱（SERS）技术相结合，开发了一种FB1传感器。以丁二酸和d-鞘氨醇为FB1的类似物，建立了双虚拟模板合成MIP的策略。基于MIP包封的银纳米粒子组成的传感器，建立了MIP- sers方法。信号放大是通过FB1对拉曼标签的竞争性位移实现的。对FB1进行SERS检测，检出限为15 ng mL−1。采用加标法和实际样品法检测谷物中FB1，回收率为89.2% % ~ 120.2 %。本研究展示了利用双假模板策略合成MIP及其在FB1快速检测中的应用。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.