Uncovering key bioactive fatty acids from velvet antler extracts that promote healthspan and neuroprotection in Caenorhabditis elegans.

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-09-24 DOI:10.1002/jsfa.70166

Ru Li, Yumin Yao, Ying Liu, Xiaohui Wang, Hongyuan Li, Yanfang Liu, Yinghua Peng

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引用次数: 0

Abstract

Background: Velvet antler has been traditionally recognized for its multifaceted health benefits, yet the underlying pharmacological mechanisms have remained poorly understood.

Results: In this study, we employed advanced analytical techniques, including liquid chromatography-mass spectrometry and gas chromatography, coupled with a Caenorhabditis elegans model, to elucidate the active small-molecule components and their associated bioactivities. Our results demonstrate that a methanol-derived velvet antler extract significantly extended the lifespan of C. elegans, enhanced physical functions such as pharyngeal pumping and body bends, and protected against toxic protein aggregation in models of Parkinson's disease (α-synuclein), Huntington's disease (polyQ), and Alzheimer's disease (Aβ). Through systematic fractionation and bioactivity-guided assays, we identified stearic acid (C18:0), linoleic acid (C18:2n), and arachidonic acid (C20:4n) as key fatty acids responsible for these health-promoting effects. Notably, a mixture of these three fatty acids at optimal concentrations conferred healthspan benefits and neuroprotection comparable to the complete extract.

Conclusion: These findings provide novel insights into the pharmacological potential of velvet antler and highlight specific fatty acids that could serve as promising therapeutic agents for aging and neurodegenerative disorders. © 2025 Society of Chemical Industry.

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揭示鹿茸提取物中促进秀丽隐杆线虫健康和神经保护的关键生物活性脂肪酸。

背景：鹿茸传统上被认为具有多方面的健康益处，但其潜在的药理机制仍然知之甚少。结果：本研究采用液相色谱-质谱联用和气相色谱等先进的分析技术，结合秀丽隐杆线虫模型，对其活性小分子成分及其相关生物活性进行了分析。我们的研究结果表明，甲醇衍生的鹿茸提取物可以显著延长秀丽隐杆线虫的寿命，增强身体功能，如咽泵和身体弯曲，并防止帕金森病（α-synuclein）、亨廷顿病（polyQ）和阿尔茨海默病（a β）模型中的有毒蛋白聚集。通过系统分离和生物活性指导试验，我们确定硬脂酸（C18:0）、亚油酸（C18:2n）和花生四烯酸（C20:4n）是这些促进健康作用的关键脂肪酸。值得注意的是，这三种脂肪酸在最佳浓度下的混合物具有与完全提取物相当的健康益处和神经保护作用。结论：这些发现为鹿茸的药理潜力提供了新的见解，并强调了特定的脂肪酸可能成为治疗衰老和神经退行性疾病的有希望的药物。©2025化学工业协会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.