{"title":"Plant-Derived Exosome-Like Nanoparticles: Innovative Nanomedicine for Therapeutic Applications","authors":"Zihan Gao, Jiajia Li, Wenhui Yang, Yuning Gu, Wenrong Xu, Zhaofeng Liang, Jiajia Jiang","doi":"10.1002/fsn3.70974","DOIUrl":null,"url":null,"abstract":"<p>Plant-derived exosome-like nanoparticles (PELNs) have demonstrated substantial potential and promising prospects in the realms of disease prevention and therapy. Composed of a diverse array of bioactive constituents and secondary metabolites, they are poised to exert significant influence in anti-inflammatory, antitumor, and antioxidant activities. Furthermore, their inherent nanomaterial properties coupled with excellent biocompatibility render PELNs natural candidates for drug delivery systems, enhancing bioavailability. This paper mainly reviews the biogenesis, isolation, and characterization of PELNs, then endeavors to synthesize the current body of knowledge on them and emphasize their potential therapeutic applications. We focus on key findings regarding anti-inflammatory, antitumor, and antioxidant effects and discuss how these insights can guide the design of next-generation nanomedicines.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70974","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science & Nutrition","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70974","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Plant-derived exosome-like nanoparticles (PELNs) have demonstrated substantial potential and promising prospects in the realms of disease prevention and therapy. Composed of a diverse array of bioactive constituents and secondary metabolites, they are poised to exert significant influence in anti-inflammatory, antitumor, and antioxidant activities. Furthermore, their inherent nanomaterial properties coupled with excellent biocompatibility render PELNs natural candidates for drug delivery systems, enhancing bioavailability. This paper mainly reviews the biogenesis, isolation, and characterization of PELNs, then endeavors to synthesize the current body of knowledge on them and emphasize their potential therapeutic applications. We focus on key findings regarding anti-inflammatory, antitumor, and antioxidant effects and discuss how these insights can guide the design of next-generation nanomedicines.
期刊介绍：
Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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