Wake-promoting therapy for prolonged disorders of consciousness: The central role of cerebral glucose metabolism

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-09-18 DOI:10.1016/j.brainresbull.2025.111557

Junjie Wang , Tong Sun , Yi Zhang , Xiaoyu Yang , Yikai Yuan , Dingkun Zhang , Junwen Guan

引用次数: 0

Abstract

With the development of neuroscience, phased achievements have been made in the treatment of patients with prolonged disorders of consciousness(pDoC), but the bottleneck of uncertain clinical efficacy remains to be broken through. This review systematically expounds the core role of glucose metabolism in the wake-promoting mechanism, and for the first time positions glucose metabolism as a common pathway for awakening in pDoC, revealing its "mechanism explanation - efficacy prediction - treatment navigation" trinity value. It proposes that glucose metabolism is the energy cornerstone for consciousness recovery, and residual glucose metabolism leads to the localization of therapeutic targets. Completing the metabolic map can guide individualized intervention. Provide theoretical support for the future development of metabolism-oriented and metabolism-responsive neural regulation schemes.

查看原文本刊更多论文

长期意识障碍的促醒治疗：脑糖代谢的核心作用。

随着神经科学的发展，在治疗延长性意识障碍（pDoC）方面取得了阶段性成果，但临床疗效不确定的瓶颈仍有待突破。本综述系统阐述了葡萄糖代谢在促醒机制中的核心作用，首次将葡萄糖代谢定位为pDoC中唤醒的共同通路，揭示了其“机制解释-疗效预测-治疗导航”三位一体的价值。这表明葡萄糖代谢是意识恢复的能量基石，剩余的葡萄糖代谢导致治疗靶点的定位。完成代谢图谱可以指导个体化干预。为未来发展代谢导向和代谢响应的神经调控方案提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.