Biomechanical finite element simulation of the pelvic organs under dynamic loading and validation against experimental data from magnetic resonance imaging

IF 2.3 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Camille Lafond , Louise Hohnadel , Thomas Brunel , Nicolas Pirrò , Marc-Emmanuel Bellemare , Dominique Chamoret , Sébastien Roth
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Abstract

Pelvic organ prolapse (POP) is a prevalent condition affecting women, particularly those over the age of 50. The etiology and pathophysiology of this condition remain poorly understood within the medical community. In recent years, researchers, particularly medical engineers and biomechanical scientists, have initiated studies on this female pathology. Numerous finite element analyses have been conducted to determine the material properties of tissues involved in POP. Building on the material properties established in prior research, this study presents a patient-specific model derived from patient-specific MRI data. Intra-abdominal pressure (IAP) and boundary conditions were determined from MRI analysis, and the models were validated against MRI simulations encompassing 11 seconds with a 1-second step interval. This study compares the outcomes of our models with MRI results, providing insights into POP biomechanics. A good correlation was observed between MRI data and the finite element method (FEM) models in healthy patients, particularly for the bladder when fluid properties, such as urine, were included. A relative error between 18% and 26% was observed for bladder displacement. Moreover, the models provided acceptable results for the uterus, vagina, and rectum. Visual results supporting these findings are presented in this study.

Abstract Image

动态载荷下盆腔器官的生物力学有限元模拟及磁共振成像实验数据验证
盆腔器官脱垂(POP)是一种影响女性的普遍疾病,特别是50岁以上的女性。这种情况的病因和病理生理学在医学界仍然知之甚少。近年来,研究人员,特别是医学工程师和生物力学科学家,开始了对这种女性病理的研究。已经进行了大量的有限元分析来确定POP中涉及的组织的材料特性。在先前研究中建立的材料特性的基础上,本研究提出了一个基于患者特异性MRI数据的患者特异性模型。通过MRI分析确定腹内压(IAP)和边界条件,并通过MRI模拟验证模型,模拟时间为11秒,步距为1秒。该研究将我们的模型结果与MRI结果进行了比较,为POP生物力学提供了见解。在健康患者中,MRI数据与有限元方法(FEM)模型之间存在良好的相关性,特别是在包括尿液等液体特性时。膀胱移位的相对误差在18%到26%之间。此外,该模型对子宫、阴道和直肠提供了可接受的结果。本研究提供了支持这些发现的视觉结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Engineering & Physics
Medical Engineering & Physics 工程技术-工程:生物医学
CiteScore
4.30
自引率
4.50%
发文量
172
审稿时长
3.0 months
期刊介绍: Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.
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