Hazardous alcohol use among patients with psychiatric disorders: Findings from phosphatidylethanol (PEth) screening in healthcare

IF 3.6 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2025-09-18 DOI:10.1016/j.addbeh.2025.108496

V. Månsson , A. Hammarberg , M. Hårdstedt , R. LoMartire

{"title":"Hazardous alcohol use among patients with psychiatric disorders: Findings from phosphatidylethanol (PEth) screening in healthcare","authors":"V. Månsson , A. Hammarberg , M. Hårdstedt , R. LoMartire","doi":"10.1016/j.addbeh.2025.108496","DOIUrl":null,"url":null,"abstract":"<div><div>Identifying hazardous alcohol use among patients with psychiatric disorders is important for improving treatment outcomes. This study aimed to describe the prevalence of hazardous alcohol use across 20 psychiatric diagnoses using phosphatidylethanol (PEth) blood sampling.</div><div>We conducted a cross-sectional analysis of PEth samples collected between 2017 and 2023 from a regional Swedish healthcare database, linked to clinician-assessed psychiatric diagnoses. Participants were adults (≥18 years) with a psychiatric disorder (N = 18,240). Hazardous alcohol use was defined as a PEth concentration > 0.30 µmol/L (∼210 µg/L). Marginal risk ratios (RR) were estimated using logistic regression adjusted for sex, age, comorbidity, season, and healthcare setting.</div><div>In the sample (mean age: 40 years; 58.7 % female), 7.4 % screened positive for hazardous use. The highest prevalence was observed in patients with substance use disorder (12 %, RR: 1.87, 95 % CI: 1.57–2.23) and panic disorder (8.8 %, RR: 1.43, 95 % CI: 1.19–1.70). Lower prevalence was seen in patients with exhaustion syndrome (5.4 %), ADHD (5.0 %), and obsessive–compulsive disorder (4.2 %). Panic disorder remained significantly associated with hazardous use after adjustment. Male sex (RR: 1.79, 95 % CI: 1.58–2.02) and age, with the highest risk observed around 60 years, were both strongly associated with increased risk.</div><div>Hazardous alcohol use is prevalent among patients with psychiatric disorders when assessed with PEth. Targeted screening, especially among older men and patients with panic disorder, may improve identification and intervention.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"172 ","pages":"Article 108496"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive behaviors","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306460325002576","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Identifying hazardous alcohol use among patients with psychiatric disorders is important for improving treatment outcomes. This study aimed to describe the prevalence of hazardous alcohol use across 20 psychiatric diagnoses using phosphatidylethanol (PEth) blood sampling.

We conducted a cross-sectional analysis of PEth samples collected between 2017 and 2023 from a regional Swedish healthcare database, linked to clinician-assessed psychiatric diagnoses. Participants were adults (≥18 years) with a psychiatric disorder (N = 18,240). Hazardous alcohol use was defined as a PEth concentration > 0.30 µmol/L (∼210 µg/L). Marginal risk ratios (RR) were estimated using logistic regression adjusted for sex, age, comorbidity, season, and healthcare setting.

In the sample (mean age: 40 years; 58.7 % female), 7.4 % screened positive for hazardous use. The highest prevalence was observed in patients with substance use disorder (12 %, RR: 1.87, 95 % CI: 1.57–2.23) and panic disorder (8.8 %, RR: 1.43, 95 % CI: 1.19–1.70). Lower prevalence was seen in patients with exhaustion syndrome (5.4 %), ADHD (5.0 %), and obsessive–compulsive disorder (4.2 %). Panic disorder remained significantly associated with hazardous use after adjustment. Male sex (RR: 1.79, 95 % CI: 1.58–2.02) and age, with the highest risk observed around 60 years, were both strongly associated with increased risk.

Hazardous alcohol use is prevalent among patients with psychiatric disorders when assessed with PEth. Targeted screening, especially among older men and patients with panic disorder, may improve identification and intervention.

查看原文本刊更多论文

精神疾病患者的危险酒精使用：医疗保健中磷脂酰乙醇（PEth）筛查的结果

确定精神障碍患者的危险酒精使用对改善治疗结果很重要。本研究旨在通过磷脂酰乙醇（PEth）血液采样来描述20种精神病诊断中有害酒精使用的流行程度。我们对2017年至2023年间从瑞典地区医疗数据库收集的PEth样本进行了横断面分析，这些样本与临床评估的精神病诊断有关。参与者为患有精神障碍的成年人（≥18岁）（N = 18,240）。有害饮酒被定义为含苯醚浓度0.30µmol/L（~ 210µg/L）。边际风险比（RR）使用经性别、年龄、合并症、季节和医疗环境调整的逻辑回归进行估计。在样本中（平均年龄：40岁；58.7%为女性），7.4%的人危险使用筛查呈阳性。物质使用障碍（12%,RR: 1.87, 95% CI: 1.57-2.23）和惊恐障碍（8.8%,RR: 1.43, 95% CI: 1.19-1.70）患者的患病率最高。疲惫综合征（5.4%）、多动症（5.0%）和强迫症（4.2%）患者的患病率较低。调整后，惊恐障碍仍与危险使用显著相关。男性（RR: 1.79, 95% CI: 1.58-2.02）和年龄（60岁左右观察到的风险最高）都与风险增加密切相关。当用PEth评估时，危险酒精使用在精神障碍患者中普遍存在。有针对性的筛查，特别是在老年男性和恐慌症患者中，可能会改善识别和干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.