Harnessing glycolysis- and cholesterol synthesis-related genes for prognostic modeling in lung adenocarcinoma.

IF 1.6 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-09-17 DOI:10.1080/10255842.2025.2559045

Jiyun Wang, Tianwei Liu, Haiyang Li, Bofeng Hou, Yanan Zhao, Feng Kai, Haoyin Tian, Yang Li, Bengang Liu

引用次数: 0

Abstract

This study aimed to construct a prognostic model for LUAD based on glycolysis- and cholesterol synthesis-related genes (GCSRGs). By performing regression analyses on expression profiles and clinical data from public databases, we established a robust risk stratification system. The results revealed significant survival differences between high- and low-risk groups, with the low-risk group exhibiting stronger immune cell infiltration and higher immune scores. Drug sensitivity analysis suggested that amonafide, AM-5992, and AZD-3147 may serve as potential therapeutic candidates. In conclusion, this model enables precise survival prediction and provides valuable insights for personalized immunotherapy and targeted treatment.

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利用糖酵解和胆固醇合成相关基因进行肺腺癌的预后建模。

我们已按要求对摘要作了必要的修改。本研究旨在构建基于糖酵解和胆固醇合成相关基因（GCSRGs）的LUAD预后模型。通过对来自公共数据库的表达谱和临床数据进行回归分析，我们建立了一个强大的风险分层系统。结果显示，高危组和低危组的生存差异显著，低危组表现出更强的免疫细胞浸润和更高的免疫评分。药物敏感性分析提示amonafide、AM-5992和AZD-3147可能是潜在的治疗候选者。总之，该模型能够精确预测生存，为个性化免疫治疗和靶向治疗提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.