{"title":"Body Positioning for Dyspnea in Patients with Cancer with Unilateral Pleural Effusion: A Pilot Trial.","authors":"Jun Kako, Yoshinobu Matsuda, Tomoo Ikari, Kozue Suzuki, Ryo Tachikawa, Yoshihisa Matsumoto, Satoru Miwa, Masanori Mori, Tetsu Kobayashi, Hajime Fujimoto, Atsushi Tomaru, Hitoshi Sumitani, Akira Inoue, Rintaro Koike, Shota Kobayashi, Shunsuke Oyamada, Keisuke Ariyoshi, Takashi Yamaguchi","doi":"10.1177/10966218251377535","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> Dyspnea is common in advanced cancer, especially with unilateral pleural effusion. Lateral positioning is widely used, but evidence of effectiveness is limited. <b><i>Objectives:</i></b> To assess the feasibility and short-term effects of affected-side-down (PLEUR-DOWN) versus affected-side-up (PLEUR-UP) positioning for dyspnea relief. <b><i>Design:</i></b> Multicenter randomized crossover pilot trial. <b><i>Setting/Subjects:</i></b> Ten patients with cancer with dyspnea were enrolled at seven hospitals in Japan. <b><i>Methods:</i></b> Patients (numerical rating scale [NRS] ≥ 3) were randomized to two sequences. Each position was maintained for five minutes within a washout period. The primary outcome was feasibility, assessed by completion, absence of carryover/period effects, and adherence. Secondary outcomes included NRS changes, patient preference, and safety. <b><i>Results:</i></b> All patients completed the trial. No significant carryover (<i>p</i> = 0.57) or period effects (<i>p</i> = 0.25) were found. Mean NRS difference favored PLEUR-DOWN (-0.9; <i>p</i> = 0.34). Half preferred PLEUR-DOWN. No adverse events occurred. <b><i>Conclusions:</i></b> The trial confirmed feasibility and supports further research.</p>","PeriodicalId":16656,"journal":{"name":"Journal of palliative medicine","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of palliative medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10966218251377535","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Dyspnea is common in advanced cancer, especially with unilateral pleural effusion. Lateral positioning is widely used, but evidence of effectiveness is limited. Objectives: To assess the feasibility and short-term effects of affected-side-down (PLEUR-DOWN) versus affected-side-up (PLEUR-UP) positioning for dyspnea relief. Design: Multicenter randomized crossover pilot trial. Setting/Subjects: Ten patients with cancer with dyspnea were enrolled at seven hospitals in Japan. Methods: Patients (numerical rating scale [NRS] ≥ 3) were randomized to two sequences. Each position was maintained for five minutes within a washout period. The primary outcome was feasibility, assessed by completion, absence of carryover/period effects, and adherence. Secondary outcomes included NRS changes, patient preference, and safety. Results: All patients completed the trial. No significant carryover (p = 0.57) or period effects (p = 0.25) were found. Mean NRS difference favored PLEUR-DOWN (-0.9; p = 0.34). Half preferred PLEUR-DOWN. No adverse events occurred. Conclusions: The trial confirmed feasibility and supports further research.
期刊介绍:
Journal of Palliative Medicine is the premier peer-reviewed journal covering medical, psychosocial, policy, and legal issues in end-of-life care and relief of suffering for patients with intractable pain. The Journal presents essential information for professionals in hospice/palliative medicine, focusing on improving quality of life for patients and their families, and the latest developments in drug and non-drug treatments.
The companion biweekly eNewsletter, Briefings in Palliative Medicine, delivers the latest breaking news and information to keep clinicians and health care providers continuously updated.