Intermittent fasting-induced autophagy normalization confers hepatic protection in metabolic dysfunction-associated fatty liver disease: Mechanistic insights and implications.

IF 2 4区 生物学 Q3 CELL BIOLOGY
Payal Bhatnagar, Gehan El-Akabawy, MoezAlIslam E Faris, Manoj B Menon, Mohamed Abdel Wahab, Farida Hussan, Mohd Hazim Bin Zulkaflee, Nabil Eid
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引用次数: 0

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic liver condition that can progress to steatohepatitis, cirrhosis, and even liver cancer. Macroautophagy (hereinafter referred to as autophagy) is a pro-survival mechanism that facilitates the lysosomal clearance of damaged organelles, abnormal proteins, and excess lipids. A growing body of evidence indicates that autophagy dysfunction and reduced autophagic flux play critical roles in the pathogenesis of MAFLD. Therefore, restoring autophagy in MAFLD may help reduce steatosis and prevent disease progression. Intermittent fasting (IF), involving periods of restricted to no food intake alternating with periods of regulated/free eating, has been demonstrated to have beneficial effects on body composition, glucose regulation, lipid profiles, and liver function in studies involving both animal models of MAFLD and human subjects. Studies involving individuals with obesity and MAFLD have shown that Ramadan intermittent fasting (RIF), an Islamic religious practice that involves abstaining from food and water intake from sunrise to sunset over approximately 30 consecutive days, significantly reduces body weight, BMI, fat mass, and inflammatory markers while improving liver function and steatosis. The hepatoprotective effects of RIF are associated with the enhanced expression of autophagy-related genes and the restoration of autophagic flux. This upregulation of autophagy as a result of RIF makes it a potentially promising therapeutic strategy for MAFLD. This review summarizes various forms of IF, the mechanisms of autophagy, and evidence of autophagy dysfunction in MAFLD. It also explores how IF, specifically RIF, may normalize autophagy, reduce hepatic steatosis, and improve liver function in human subjects.

间歇性禁食诱导的自噬正常化在代谢功能障碍相关的脂肪肝疾病中赋予肝脏保护:机制见解和意义
代谢功能障碍相关脂肪性肝病(MAFLD)是一种慢性肝病,可发展为脂肪性肝炎、肝硬化甚至肝癌。巨噬(Macroautophagy,以下简称自噬)是促进溶酶体清除受损细胞器、异常蛋白和过量脂质的促生存机制。越来越多的证据表明,自噬功能障碍和自噬通量减少在MAFLD的发病机制中起关键作用。因此,在MAFLD中恢复自噬可能有助于减少脂肪变性和预防疾病进展。在涉及动物模型和人类受试者的研究中,间歇性禁食(IF),包括限制或不进食与调节/自由进食交替的时期,已被证明对身体成分、葡萄糖调节、脂质分布和肝功能有有益的影响。针对肥胖和MAFLD患者的研究表明,斋月间歇禁食(RIF)是一种伊斯兰宗教习俗,涉及从日出到日落连续大约30天不吃东西和喝水,可以显著降低体重、BMI、脂肪量和炎症标志物,同时改善肝功能和脂肪变性。RIF的肝保护作用与增强自噬相关基因的表达和自噬通量的恢复有关。RIF导致的自噬上调使其成为一种潜在的有前景的治疗MAFLD的策略。本文综述了各种形式的IF、自噬机制以及mald中自噬功能障碍的证据。它还探讨了IF,特别是RIF如何使人类受试者的自噬正常化,减少肝脂肪变性和改善肝功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Histology and histopathology
Histology and histopathology 生物-病理学
CiteScore
3.90
自引率
0.00%
发文量
232
审稿时长
2 months
期刊介绍: HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.
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