Oxytocin signaling regulates maternally directed behavior during early life

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-09-11 DOI:10.1126/science.ado5609

Daniel D. Zelmanoff, Rebecca Bornstein, Menachem Kaufman, Julien Dine, Jonas Wietek, Anna Litvin, Shaked Abraham, Savanna Cohen, Ayelet Atzmon, Ido Porat, Ofer Yizhar

引用次数: 0

Abstract

Oxytocin is essential in shaping social behavior across the lifespan. Although the role of oxytocin signaling in parental care has been widely investigated, little is known about its function in social behavior during early life. We studied the role of oxytocin in mouse pup social behavior during acute separation from the mother as well as upon reunion. The activity of oxytocin neurons was increased by acute maternal separation. Behaviorally, maternally separated pups emitted more ultrasonic vocalizations upon reunion, which were further modulated by nipple attachment behavior. These effects were attenuated by blocking the oxytocin receptor during maternal separation. Optogenetic silencing of oxytocin neurons during maternal separation disrupted vocal behavior during separation and reunion. Our findings reveal an important role of oxytocin in context-dependent vocal communication in mouse pups.

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催产素信号调节母亲在生命早期的行为。

催产素在一生中塑造社会行为是必不可少的。尽管催产素信号在亲代抚育中的作用已被广泛研究，但其在早期社会行为中的作用却鲜为人知。我们研究了催产素在小鼠幼崽与母亲急性分离以及团聚时的社会行为中的作用。母体急性分离后催产素神经元活性增加。在行为上，母鼠分离后的幼崽在团聚时发出更多的超声波，这进一步受到乳头附着行为的调节。在母体分离期间，阻断催产素受体可减弱这些影响。在母亲分离期间，光遗传沉默催产素神经元破坏了分离和团聚期间的发声行为。我们的研究结果揭示了催产素在小鼠幼崽的语境依赖性声音交流中的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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