Recent Advances in the Isolation, Bioactivity, Biosynthesis, and Total Synthesis of Hamigerans
IF 3.6
2区 生物学
Q2 CHEMISTRY, MEDICINAL
引用次数: 0
Abstract
Hamigerans, a class of diterpenoid natural products isolated from marine sponge Hamigera tarangaensis, are characterized by distinctive 6–6–5 or 6–7–5 tricyclic skeletons. These compounds have been a focal point for synthetic chemists in recent years due to their remarkable biological activities. In this Review, we summarize the progress made in the isolation, biosynthesis, bioactivity, and total synthesis of hamigerans, with particular emphasis on synthetic studies published since 2013. Our goal for this Review is to provide new insights for future research on this class of marine natural products.
Hamigerans的分离、生物活性、生物合成和全合成研究进展。
Hamigerans是一类从海绵Hamigera tarangaensis中分离出来的二萜类天然产物，具有独特的6-6-5或6-7-5三环骨架。这些化合物由于具有显著的生物活性，近年来一直是合成化学家关注的焦点。本文综述了hamigerans的分离、生物合成、生物活性和全合成方面的研究进展，重点介绍了2013年以来hamigerans的合成研究。本文的目的是为今后这类海洋天然产物的研究提供新的思路。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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