Microglia-Astroglia-Neuron network following stroke: Novel insight into extracellular vesicles communication

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-09-05 DOI:10.1016/j.brainresbull.2025.111537

Hao Wan , Yicheng Cui , Yanyang Zeng , Jianbin Hu , Meihua Li , Zhipeng Xiao

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引用次数: 0

Abstract

Stroke is one of the leading causes of death and disability worldwide, with ischemic stroke accounting for the majority of cases. Intercellular communication is critical to its prognostic impact, and extracellular vesicles (EVs) are an emerging important mechanism. EVs are increasingly recognized as key mediators of crosstalk between neurons and glial cells, affecting processes such as neuroinflammation, oxidative stress and tissue repair. More previous studies have focused on signaling and information exchange between the two types of cells. This paper reviews the EVs-mediated triad interaction between neurons, astrocytes and microglia after stroke based on the spatiotemporal entanglement of them. Not only the intercellular crosstalk of EVs of microglial, astrocytic, or neuronal origins is explored in detail, the cargoes carried by EVs and their mechanisms of action are resolved, but also the overlapping parts in the EVs-mediated cellular communication mechanisms are analyzed, such as the NF-κB signaling pathway and miR-124 which play an important and complex role in a variety of intercellular communications. On this basis, EVs were revealed to have potential as biomarkers and therapeutic carriers. The aim of this paper is to contribute to our deeper understanding of stroke pathophysiology and to inspire new possible therapeutic strategies.

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中风后的小胶质细胞-星形胶质细胞-神经元网络：细胞外囊泡通讯的新见解。

中风是全世界死亡和残疾的主要原因之一，缺血性中风占大多数病例。细胞间通讯对其预后影响至关重要，细胞外囊泡（EVs）是一种新兴的重要机制。电动汽车越来越被认为是神经元和神经胶质细胞之间串扰的关键介质，影响神经炎症、氧化应激和组织修复等过程。之前更多的研究集中在两种细胞之间的信号和信息交换。本文基于脑卒中后神经元、星形胶质细胞和小胶质细胞的时空纠缠，综述了ev介导的脑卒中后神经元、星形胶质细胞和小胶质细胞之间的三元相互作用。本文不仅详细探讨了小胶质细胞、星形胶质细胞或神经元起源的电动汽车的细胞间串扰，解析了电动汽车所携带的货物及其作用机制，还分析了电动汽车介导的细胞通讯机制中的重叠部分，如NF-κB信号通路和miR-124，它们在各种细胞间通讯中起着重要而复杂的作用。在此基础上，ev具有作为生物标志物和治疗载体的潜力。本文的目的是促进我们对脑卒中病理生理学的深入了解，并激发新的可能的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.