Lactylation formation, gene regulation, biological functions, and clinical relevance.

IF 2 4区 生物学 Q3 CELL BIOLOGY
Xiaoyu Wei, Zhimei Qiu, Youyang Huang, Qing Guo, Ying Li, Yongchao Zhao, Bei Shi
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引用次数: 0

Abstract

Lactate, as an end-product of glycolysis, has been considered as a metabolic waste that participates in a few physiological functions. Recently, a novel study by Zhao's laboratory reported that lactate can serve as an epigenetic modification substrate, causing histone or nonhistone lysine residues to undergo lactylation, which then regulates gene transcription, translation, and protein function. Subsequent studies confirmed that lactylation plays an important role in a series of physiological and pathological processes, such as inflammation, cancer, and other biological processes. In this review, we summarize advanced achievements on the effects of lactylation in various diseases and potential treatment targets, providing a reference and direction for future research.

乳酸化形成、基因调控、生物学功能和临床相关性。
乳酸作为糖酵解的最终产物,被认为是一种参与一些生理功能的代谢废物。最近,Zhao实验室的一项新研究报道,乳酸可以作为一种表观遗传修饰底物,使组蛋白或非组蛋白赖氨酸残基发生乳酸化,从而调节基因转录、翻译和蛋白质功能。随后的研究证实,乳酸化在一系列生理和病理过程中发挥重要作用,如炎症、癌症等生物学过程。本文就乳酸化作用在各种疾病中的作用及潜在的治疗靶点等方面的最新研究成果进行综述,为今后的研究提供参考和方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Histology and histopathology
Histology and histopathology 生物-病理学
CiteScore
3.90
自引率
0.00%
发文量
232
审稿时长
2 months
期刊介绍: HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.
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